Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49212..50010 Replicon chromosome
Accession NZ_CP027118
Organism Escherichia coli strain 26561

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag CYQ10_RS00285 Protein ID WP_000854735.1
Coordinates 49212..49589 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag CYQ10_RS00290 Protein ID WP_001285415.1
Coordinates 49636..50010 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYQ10_RS00250 44559..45482 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
CYQ10_RS00255 45593..46777 - 1185 WP_001172876.1 sugar efflux transporter -
CYQ10_RS00270 47573..48415 - 843 WP_000036706.1 DUF4942 domain-containing protein -
CYQ10_RS00275 48512..48709 - 198 WP_000839266.1 DUF957 domain-containing protein -
CYQ10_RS00280 48727..49215 - 489 WP_000761680.1 hypothetical protein -
CYQ10_RS00285 49212..49589 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
CYQ10_RS00290 49636..50010 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CYQ10_RS00295 50090..50311 - 222 WP_000692309.1 DUF987 domain-containing protein -
CYQ10_RS00300 50374..50850 - 477 WP_001366855.1 RadC family protein -
CYQ10_RS00305 50866..51351 - 486 WP_061362230.1 antirestriction protein -
CYQ10_RS00310 51443..52261 - 819 WP_001175166.1 DUF945 domain-containing protein -
CYQ10_RS00315 52351..52584 - 234 WP_001278287.1 DUF905 family protein -
CYQ10_RS00320 52590..53267 - 678 WP_001097301.1 hypothetical protein -
CYQ10_RS00325 53415..54095 - 681 WP_001282914.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T97333 WP_000854735.1 NZ_CP027118:c49589-49212 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T97333 NZ_CP027118:c49589-49212 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT97333 WP_001285415.1 NZ_CP027118:c50010-49636 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT97333 NZ_CP027118:c50010-49636 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References