Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4746075..4746682 Replicon chromosome
Accession NZ_CP027111
Organism Enterobacter hormaechei strain BW

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C5I89_RS22650 Protein ID WP_017382585.1
Coordinates 4746497..4746682 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C5I89_RS22645 Protein ID WP_017382586.1
Coordinates 4746075..4746482 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5I89_RS22615 4741921..4742574 + 654 WP_017382590.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
C5I89_RS22620 4742577..4743437 + 861 WP_017382589.1 L-ribulose-5-phosphate 3-epimerase -
C5I89_RS22625 4743431..4744126 + 696 WP_017382588.1 L-ribulose-5-phosphate 4-epimerase -
C5I89_RS22630 4744127..4744414 - 288 Protein_4431 helix-turn-helix domain-containing protein -
C5I89_RS22635 4744421..4744789 + 369 Protein_4432 glycoside hydrolase family 127 protein -
C5I89_RS22640 4744996..4746071 + 1076 Protein_4433 type I restriction enzyme HsdR N-terminal domain-containing protein -
C5I89_RS22645 4746075..4746482 - 408 WP_017382586.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C5I89_RS22650 4746497..4746682 - 186 WP_017382585.1 type II toxin-antitoxin system HicA family toxin Toxin
C5I89_RS22655 4746932..4748470 - 1539 WP_161503939.1 aldehyde dehydrogenase AldB -
C5I89_RS22660 4748637..4749521 + 885 WP_161503940.1 ROK family protein -
C5I89_RS22665 4749525..4751363 - 1839 WP_017382583.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6794.98 Da        Isoelectric Point: 11.4624

>T97327 WP_017382585.1 NZ_CP027111:c4746682-4746497 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTTGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T97327 NZ_CP027111:c4746682-4746497 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGACGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15171.94 Da        Isoelectric Point: 4.3197

>AT97327 WP_017382586.1 NZ_CP027111:c4746482-4746075 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEAFPLPGNVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPR

Download         Length: 408 bp

>AT97327 NZ_CP027111:c4746482-4746075 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCCGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGACGCTTTTCAGGATGCACGTGATGCGCTCACGGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTTCCTCTCCCGGGTAATGTCGAAGTGCACCTTGAAAATCAACCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAATTCGACGGCAGAGCCGAACGCATCAACATCACGATGCCTCGACGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References