Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3990647..3991304 Replicon chromosome
Accession NZ_CP027111
Organism Enterobacter hormaechei strain BW

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag C5I89_RS18945 Protein ID WP_017382887.1
Coordinates 3990647..3991057 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag C5I89_RS18950 Protein ID WP_003863437.1
Coordinates 3991038..3991304 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5I89_RS18925 3986645..3988378 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
C5I89_RS18930 3988384..3989097 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C5I89_RS18935 3989126..3990022 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
C5I89_RS18940 3990124..3990645 + 522 WP_015571793.1 flavodoxin FldB -
C5I89_RS18945 3990647..3991057 - 411 WP_017382887.1 protein YgfX Toxin
C5I89_RS18950 3991038..3991304 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
C5I89_RS18955 3991599..3992579 + 981 WP_017382888.1 tRNA-modifying protein YgfZ -
C5I89_RS18960 3992691..3993350 - 660 WP_017382889.1 hemolysin III family protein -
C5I89_RS18965 3993617..3994348 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
C5I89_RS18970 3994465..3995898 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T97326 WP_017382887.1 NZ_CP027111:c3991057-3990647 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T97326 NZ_CP027111:c3991057-3990647 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGTTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT97326 WP_003863437.1 NZ_CP027111:c3991304-3991038 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT97326 NZ_CP027111:c3991304-3991038 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References