Detailed information of TA system TA097324

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 3681907..3682633
• Replicon: chromosome
• Accession: NZ_CP027111
• Organism: Enterobacter hormaechei strain BW

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: C5I89_RS17490
• Protein ID: WP_072035667.1
• Coordinates: 3682304..3682633 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: C5I89_RS17485
• Protein ID: WP_042893201.1
• Coordinates: 3681907..3682266 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5I89_RS17435	3677403..3677810	+	408	WP_042893215.1	hypothetical protein	-
C5I89_RS17440	3677883..3678110	+	228	WP_042893214.1	hypothetical protein	-
C5I89_RS17445	3678191..3678355	+	165	WP_154816236.1	hypothetical protein	-
C5I89_RS17450	3678413..3679249	+	837	WP_045341439.1	hypothetical protein	-
C5I89_RS17455	3679343..3679576	+	234	WP_042893208.1	DUF905 family protein	-
C5I89_RS17460	3679674..3680492	+	819	WP_042893207.1	DUF945 domain-containing protein	-
C5I89_RS17465	3680492..3680746	+	255	WP_072035668.1	hypothetical protein	-
C5I89_RS17470	3680762..3681157	+	396	WP_045341441.1	antirestriction protein	-
C5I89_RS17475	3681169..3681648	+	480	WP_042893205.1	DNA repair protein RadC	-
C5I89_RS17480	3681663..3681884	+	222	WP_042893203.1	DUF987 domain-containing protein	-
C5I89_RS17485	3681907..3682266	+	360	WP_042893201.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C5I89_RS17490	3682304..3682633	+	330	WP_072035667.1	TA system toxin CbtA family protein	Toxin
C5I89_RS17495	3683263..3684501	+	1239	WP_045341443.1	ribokinase	-
C5I89_RS17500	3684569..3685546	+	978	WP_017692843.1	sugar ABC transporter permease	-
C5I89_RS17505	3685546..3686445	+	900	WP_017692842.1	carbohydrate ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3650079..3682633	32554

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (15-115)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12450.17 Da
• Isoelectric Point: 10.5232

>T97324 WP_072035667.1 NZ_CP027111:3682304-3682633 [Enterobacter hormaechei]
MQTLSSHSTRATQPNLSPVKTWQRLLTHLLSQHYGLRLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILRARRSTGLLKTNVK

Nucleotide

• Length: 330 bp

>T97324 NZ_CP027111:3682304-3682633 [Enterobacter hormaechei]
ATGCAAACCTTATCATCACACTCGACACGGGCGACTCAGCCCAATCTGTCACCCGTTAAAACCTGGCAACGGCTGCTGAC
TCATCTGTTATCGCAGCACTATGGCCTGAGGTTGAATGACACACCGTTCAGTAATGAAACCACCATACGAGAACATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAGTACGGGCTTGTCCGTATCGATCGGAAGGGATTT
TCATGGCAAGAACAAACCCCGTATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13412.23 Da
• Isoelectric Point: 5.8752

>AT97324 WP_042893201.1 NZ_CP027111:3681907-3682266 [Enterobacter hormaechei]
MQNTTPVANHDIAEPWWGLKPTVTPCLGARLVQEGNRLHYLADPASITGTFNNEDLRHLDQAFPVLLKQLELMLVSGELT
SRYQHRITLYHNRLTCEADTLGSCGYVCIAIYPDQPEPH

Nucleotide

• Length: 360 bp

>AT97324 NZ_CP027111:3681907-3682266 [Enterobacter hormaechei]
ATGCAGAACACAACACCTGTAGCAAACCATGATATTGCCGAACCCTGGTGGGGACTTAAACCCACCGTCACGCCGTGTCT
TGGCGCACGGCTGGTACAGGAAGGCAACCGGCTGCATTATCTGGCTGACCCGGCAAGTATCACCGGAACATTCAACAATG
AGGATTTACGTCATCTCGACCAGGCGTTTCCGGTATTGCTTAAACAGCTGGAGTTGATGCTCGTTTCCGGTGAGCTCACC
TCCCGCTATCAGCACCGCATCACGCTATATCACAATAGACTGACTTGCGAAGCTGACACACTCGGCTCCTGTGGCTATGT
CTGCATCGCTATTTATCCCGACCAGCCTGAACCCCATTAA