Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2406130..2406869 Replicon chromosome
Accession NZ_CP027111
Organism Enterobacter hormaechei strain BW

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag C5I89_RS11505 Protein ID WP_003857133.1
Coordinates 2406130..2406615 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag C5I89_RS11510 Protein ID WP_003857131.1
Coordinates 2406603..2406869 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5I89_RS11475 2401628..2402242 + 615 WP_080337195.1 NUDIX hydrolase -
C5I89_RS11480 2402426..2403061 - 636 WP_015570517.1 DUF421 domain-containing protein -
C5I89_RS11485 2403071..2403517 - 447 WP_014069654.1 DUF3290 domain-containing protein -
C5I89_RS11490 2403946..2404274 - 329 Protein_2243 helix-turn-helix domain-containing protein -
C5I89_RS11495 2404529..2405494 + 966 WP_045338503.1 hypothetical protein -
C5I89_RS11500 2405510..2406079 + 570 WP_017382346.1 hypothetical protein -
C5I89_RS11505 2406130..2406615 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
C5I89_RS11510 2406603..2406869 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
C5I89_RS11515 2406933..2407862 - 930 WP_026080525.1 LysR family transcriptional regulator -
C5I89_RS11520 2407992..2409380 + 1389 WP_017382343.1 MFS transporter -
C5I89_RS11525 2409403..2410398 - 996 WP_017382342.1 DUF2891 domain-containing protein -
C5I89_RS11530 2410408..2411394 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17572.29 Da        Isoelectric Point: 9.9658

>T97315 WP_003857133.1 NZ_CP027111:c2406615-2406130 [Enterobacter hormaechei]
MGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T97315 NZ_CP027111:c2406615-2406130 [Enterobacter hormaechei]
ATGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACCTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGGAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCAGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT97315 WP_003857131.1 NZ_CP027111:c2406869-2406603 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT97315 NZ_CP027111:c2406869-2406603 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCGGCCATAGAAAAACTGCTG
GCAAGGAAACCACAATGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References