Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4187227..4187890 Replicon chromosome
Accession NZ_CP027107
Organism Cronobacter sakazakii strain CS-931

Toxin (Protein)


Gene name cptA Uniprot ID A0A7V7RBD3
Locus tag CsakCS931_RS19855 Protein ID WP_029039029.1
Coordinates 4187474..4187890 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7V7RBN7
Locus tag CsakCS931_RS19850 Protein ID WP_007892598.1
Coordinates 4187227..4187493 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CsakCS931_RS19825 4182256..4183689 - 1434 WP_007892604.1 6-phospho-beta-glucosidase -
CsakCS931_RS19830 4183841..4184569 - 729 WP_032975612.1 MurR/RpiR family transcriptional regulator -
CsakCS931_RS19835 4184745..4185059 + 315 WP_007892602.1 N(4)-acetylcytidine aminohydrolase -
CsakCS931_RS19840 4185202..4185855 + 654 WP_007777939.1 hemolysin III family protein -
CsakCS931_RS19845 4185960..4186949 - 990 WP_007892600.1 tRNA-modifying protein YgfZ -
CsakCS931_RS19850 4187227..4187493 + 267 WP_007892598.1 FAD assembly factor SdhE Antitoxin
CsakCS931_RS19855 4187474..4187890 + 417 WP_029039029.1 protein YgfX Toxin
CsakCS931_RS19860 4187904..4188425 - 522 WP_004385676.1 flavodoxin FldB -
CsakCS931_RS19865 4188527..4189423 + 897 WP_007892593.1 site-specific tyrosine recombinase XerD -
CsakCS931_RS19870 4189446..4190165 + 720 WP_004385678.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CsakCS931_RS19875 4190169..4191902 + 1734 WP_007870697.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16342.30 Da        Isoelectric Point: 11.2018

>T97313 WP_029039029.1 NZ_CP027107:4187474-4187890 [Cronobacter sakazakii]
VVLWHSDLRVSWRSQWLSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYHLRWQGV
DWQICATPWMLRSGMMLRLGHPKTTRRHHVWLAADSMTEAEWRDLRRLLLQQPVGDKR

Download         Length: 417 bp

>T97313 NZ_CP027107:4187474-4187890 [Cronobacter sakazakii]
GTGGTCCTGTGGCACTCTGATCTTCGCGTTTCATGGCGCTCGCAGTGGCTATCGCTGCTGCTGCACGGCGCCGTGGCCGT
TATTATTTTGCTGCTCCCCTGGCCGCTGCGGTATCTGCCCGTGTGGATGCTGTTGCTGTCTCTGGTGGTGTTTGACTGCG
TACGTAGCCAGCGGCGTATCAATGCGTTCCAGGGCGAGGTCAGCCTGACGGCTGATTATCACCTTCGCTGGCAGGGCGTT
GACTGGCAGATTTGCGCCACGCCCTGGATGCTGCGCAGCGGAATGATGCTGCGGCTGGGTCATCCTAAAACGACACGCCG
CCATCATGTCTGGCTGGCGGCGGATAGCATGACGGAAGCAGAGTGGCGCGATTTGCGTCGCCTTCTGTTGCAACAGCCCG
TAGGCGACAAACGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10427.89 Da        Isoelectric Point: 4.8310

>AT97313 WP_007892598.1 NZ_CP027107:4187227-4187493 [Cronobacter sakazakii]
MDINNKARIHWACRRGMRELDISIMPFFEYDYDSLSDEDKRVFVRLLECDDPDLFNWLMNHGKPADSELARMVELIQQRN
QARGPVAL

Download         Length: 267 bp

>AT97313 NZ_CP027107:4187227-4187493 [Cronobacter sakazakii]
ATGGATATTAATAATAAAGCCCGTATTCACTGGGCATGTCGCAGAGGTATGCGCGAGCTGGATATTTCCATCATGCCTTT
CTTTGAATATGACTATGACTCCCTGAGCGACGAAGACAAACGCGTTTTTGTCCGCCTGCTGGAGTGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCAGCTGATTCGGAGCTGGCGCGAATGGTGGAATTAATCCAGCAGCGGAAT
CAGGCACGTGGTCCTGTGGCACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7RBD3

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7RBN7

References