Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4030193..4030712 Replicon chromosome
Accession NZ_CP027107
Organism Cronobacter sakazakii strain CS-931

Toxin (Protein)


Gene name relE Uniprot ID A0A7V7RC92
Locus tag CsakCS931_RS19085 Protein ID WP_007871045.1
Coordinates 4030425..4030712 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7V7UQR6
Locus tag CsakCS931_RS19080 Protein ID WP_029038981.1
Coordinates 4030193..4030435 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CsakCS931_RS19065 4026236..4027354 + 1119 WP_097573794.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
CsakCS931_RS19070 4027351..4028091 + 741 WP_007897814.1 KDGP aldolase family protein -
CsakCS931_RS19075 4028205..4030115 + 1911 WP_007897812.1 BglG family transcription antiterminator -
CsakCS931_RS19080 4030193..4030435 + 243 WP_029038981.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CsakCS931_RS19085 4030425..4030712 + 288 WP_007871045.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CsakCS931_RS19090 4030720..4031184 - 465 WP_007897806.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CsakCS931_RS19095 4031326..4033461 - 2136 WP_007897804.1 anaerobic ribonucleoside-triphosphate reductase -
CsakCS931_RS19100 4033757..4034638 - 882 WP_007897803.1 LysR family transcriptional regulator -
CsakCS931_RS19105 4034741..4035271 + 531 WP_097573793.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10837.83 Da        Isoelectric Point: 10.4974

>T97312 WP_007871045.1 NZ_CP027107:4030425-4030712 [Cronobacter sakazakii]
MSYKLVFDPRALKEWHKLGETVKAQFKKKLAYVLAAPRVKSARLSGLPDCYKIKLRTSGYRLVYQVRDDAVCVLVIAIGK
RENLTVYQGAGHRLE

Download         Length: 288 bp

>T97312 NZ_CP027107:4030425-4030712 [Cronobacter sakazakii]
ATGAGCTATAAACTGGTCTTTGACCCACGTGCGCTGAAGGAGTGGCACAAACTGGGCGAGACCGTTAAAGCGCAATTCAA
AAAGAAGCTGGCGTACGTGCTGGCGGCTCCCAGGGTGAAATCCGCCCGGTTAAGTGGCCTGCCGGACTGCTACAAAATTA
AATTAAGAACGAGCGGTTACCGGCTGGTGTATCAGGTGCGCGATGATGCTGTCTGTGTGCTGGTCATCGCGATCGGCAAA
CGCGAAAACCTGACCGTATACCAGGGTGCCGGGCACCGTCTGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8965.39 Da        Isoelectric Point: 6.3131

>AT97312 WP_029038981.1 NZ_CP027107:4030193-4030435 [Cronobacter sakazakii]
MATINVRLDDKLKNEAYAVLGKLGITPTEAVRLLFQYVAQNGRMPVKTLTVSDSEEALLRTVRERLADPRPGIRVDLDEL

Download         Length: 243 bp

>AT97312 NZ_CP027107:4030193-4030435 [Cronobacter sakazakii]
ATGGCCACAATCAACGTAAGGCTTGATGACAAGCTTAAAAATGAGGCTTATGCGGTGCTGGGAAAACTGGGTATCACACC
TACCGAAGCGGTGCGTCTGCTGTTTCAGTATGTGGCGCAAAATGGCCGTATGCCAGTCAAAACGCTAACCGTCAGCGACA
GCGAAGAGGCGCTGCTGCGTACCGTGCGGGAGCGACTGGCGGACCCGCGGCCGGGCATCAGGGTTGATCTGGATGAGCTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7RC92

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7UQR6

References