97311

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 3838821..3839491 Replicon chromosome
Accession NZ_CP027107
Organism Cronobacter sakazakii strain CS-931

Toxin (Protein)


Gene name tad Uniprot ID A0A7V7RAE9
Locus tag CsakCS931_RS18180 Protein ID WP_007891559.1
Coordinates 3838821..3839171 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A7V7RA28
Locus tag CsakCS931_RS18185 Protein ID WP_007891558.1
Coordinates 3839168..3839491 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CsakCS931_RS18165 3836371..3838002 + 1632 WP_007891561.1 Na/Pi cotransporter family protein -
CsakCS931_RS18170 3838019..3838294 - 276 WP_007852536.1 putative addiction module antidote protein -
CsakCS931_RS18175 3838299..3838604 - 306 WP_014727945.1 type II toxin-antitoxin system RelE/ParE family toxin -
CsakCS931_RS18180 3838821..3839171 + 351 WP_007891559.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CsakCS931_RS18185 3839168..3839491 + 324 WP_007891558.1 helix-turn-helix domain-containing protein Antitoxin
CsakCS931_RS18190 3839518..3839790 - 273 WP_007702377.1 DUF3811 domain-containing protein -
CsakCS931_RS18195 3839881..3840816 - 936 WP_007891556.1 ketopantoate/pantoate/pantothenate transporter PanS -
CsakCS931_RS18200 3840978..3842570 - 1593 WP_007891554.1 RNA repair transcriptional activator RtcR -
CsakCS931_RS18205 3843046..3844179 + 1134 WP_029039413.1 slipin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12982.04 Da        Isoelectric Point: 10.0998

>T97311 WP_007891559.1 NZ_CP027107:3838821-3839171 [Cronobacter sakazakii]
MIKPLFWVGQARKDLQALPEDVQDLFGYALYLAQQGRRHPQARPLKGFGGAGVLEVVEDYQGNAFRAVYTVCLKDAIYVL
HVFQKKSSSGIATPRPEMEKIEQRLKAAQRHAGGLK

Download         Length: 351 bp

>T97311 NZ_CP027107:3838821-3839171 [Cronobacter sakazakii]
ATGATAAAACCGTTGTTTTGGGTCGGGCAGGCCAGAAAAGATCTTCAGGCGCTGCCGGAGGATGTACAGGATCTTTTTGG
CTATGCGCTTTATCTGGCGCAGCAGGGTAGACGCCATCCGCAGGCCAGGCCGCTTAAAGGTTTTGGCGGCGCGGGTGTAC
TTGAGGTGGTGGAGGATTATCAGGGGAATGCCTTTCGGGCGGTCTATACCGTGTGTCTGAAAGATGCGATTTATGTCCTG
CACGTATTCCAGAAAAAATCCTCTTCCGGGATTGCCACGCCCCGCCCGGAGATGGAAAAAATTGAACAACGACTGAAAGC
CGCGCAACGCCACGCCGGAGGGCTGAAATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11781.84 Da        Isoelectric Point: 6.3117

>AT97311 WP_007891558.1 NZ_CP027107:3839168-3839491 [Cronobacter sakazakii]
MTADIERSNGNVYDDLGLIDAEEMQLKAQLAMAVSDILKARGLTQQEAARLLGMTQPKLSLLLRGQFRGISETKMMACLM
LLGRDISIVVGEAQQARGKMRLIYEPA

Download         Length: 324 bp

>AT97311 NZ_CP027107:3839168-3839491 [Cronobacter sakazakii]
ATGACAGCAGACATTGAACGCAGTAACGGAAATGTGTATGACGATCTCGGGCTTATCGACGCCGAAGAGATGCAGCTAAA
AGCGCAGCTCGCTATGGCCGTTAGCGACATTCTTAAAGCGCGCGGCTTAACCCAGCAGGAGGCGGCCCGTCTTCTGGGCA
TGACCCAGCCAAAACTTTCTTTATTACTTCGCGGCCAGTTTCGCGGGATCAGCGAAACGAAAATGATGGCCTGCCTGATG
CTCCTCGGGCGGGATATCAGTATCGTCGTCGGCGAAGCACAACAGGCGCGCGGAAAAATGCGCCTGATTTATGAGCCAGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7RAE9

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7RA28

References