Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 3838019..3838604 Replicon chromosome
Accession NZ_CP027107
Organism Cronobacter sakazakii strain CS-931

Toxin (Protein)


Gene name PumA Uniprot ID A0A853H7C5
Locus tag CsakCS931_RS18175 Protein ID WP_014727945.1
Coordinates 3838299..3838604 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A2S9UB62
Locus tag CsakCS931_RS18170 Protein ID WP_007852536.1
Coordinates 3838019..3838294 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CsakCS931_RS18165 3836371..3838002 + 1632 WP_007891561.1 Na/Pi cotransporter family protein -
CsakCS931_RS18170 3838019..3838294 - 276 WP_007852536.1 putative addiction module antidote protein Antitoxin
CsakCS931_RS18175 3838299..3838604 - 306 WP_014727945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CsakCS931_RS18180 3838821..3839171 + 351 WP_007891559.1 type II toxin-antitoxin system RelE/ParE family toxin -
CsakCS931_RS18185 3839168..3839491 + 324 WP_007891558.1 helix-turn-helix domain-containing protein -
CsakCS931_RS18190 3839518..3839790 - 273 WP_007702377.1 DUF3811 domain-containing protein -
CsakCS931_RS18195 3839881..3840816 - 936 WP_007891556.1 ketopantoate/pantoate/pantothenate transporter PanS -
CsakCS931_RS18200 3840978..3842570 - 1593 WP_007891554.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11588.58 Da        Isoelectric Point: 10.3395

>T97310 WP_014727945.1 NZ_CP027107:c3838604-3838299 [Cronobacter sakazakii]
MKHIFQTEVFRRWQASLKDQRVKTMIAARLFRLANGLPGDVKPVGAGISELRIHYGAGYRIYFKQHGEVIVILLCGGDKH
TQDKDILLAKMLADLPENQWR

Download         Length: 306 bp

>T97310 NZ_CP027107:c3838604-3838299 [Cronobacter sakazakii]
ATGAAGCATATTTTTCAAACTGAAGTATTCCGCCGTTGGCAAGCCAGTCTGAAAGACCAGCGGGTAAAAACGATGATTGC
CGCGCGGCTTTTTCGGCTGGCTAATGGTTTGCCTGGTGATGTTAAGCCCGTCGGCGCAGGCATCAGTGAACTGCGTATTC
ACTACGGCGCGGGTTACCGGATTTATTTCAAACAACACGGCGAGGTGATTGTCATTTTGCTTTGTGGTGGTGATAAGCAC
ACGCAGGATAAAGACATTCTTCTTGCGAAAATGCTGGCTGACCTGCCAGAGAACCAGTGGAGATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9597.06 Da        Isoelectric Point: 6.4609

>AT97310 WP_007852536.1 NZ_CP027107:c3838294-3838019 [Cronobacter sakazakii]
MKLTEYDPAAALVDDEEIAFFMADALETGDAGHIAKALGVVARAKGMSHIAAQTGLSREQLYRSFSDKGNPTLKTTLAVM
KALGLGLTVKS

Download         Length: 276 bp

>AT97310 NZ_CP027107:c3838294-3838019 [Cronobacter sakazakii]
ATGAAGCTGACCGAATACGATCCCGCAGCGGCGCTGGTAGATGATGAGGAGATCGCCTTCTTTATGGCGGACGCGCTCGA
AACTGGCGACGCCGGACATATTGCAAAGGCGCTGGGCGTCGTCGCGCGCGCTAAAGGCATGTCGCATATCGCCGCTCAGA
CAGGGCTGTCGCGTGAACAGCTGTACCGTTCTTTCAGTGATAAAGGCAACCCAACGCTTAAAACCACGCTGGCAGTGATG
AAAGCGTTGGGTCTCGGTTTAACGGTTAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853H7C5

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9UB62

References