Detailed information of TA system TA097309

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 3645233..3645699
• Replicon: chromosome
• Accession: NZ_CP027107
• Organism: Cronobacter sakazakii strain CS-931

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A2S9UG96
• Locus tag: CsakCS931_RS17195
• Protein ID: WP_007797229.1
• Coordinates: 3645233..3645508 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CsakCS931_RS17200
• Protein ID: WP_076727147.1
• Coordinates: 3645508..3645699 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CsakCS931_RS17180	3641332..3642174	-	843	WP_038859483.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
CsakCS931_RS17185	3642367..3644409	+	2043	WP_007899954.1	oligopeptidase A	-
CsakCS931_RS17190	3644418..3645170	+	753	WP_007899951.1	16S rRNA (guanine(1516)-N(2))-methyltransferase RsmJ	-
CsakCS931_RS17195	3645233..3645508	-	276	WP_007797229.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CsakCS931_RS17200	3645508..3645699	-	192	WP_076727147.1	stability determinant	Antitoxin
CsakCS931_RS17205	3645874..3646311	-	438	WP_004388310.1	universal stress protein UspA	-
CsakCS931_RS17210	3646702..3647037	+	336	WP_007899947.1	universal stress protein UspB	-
CsakCS931_RS17215	3647088..3648590	-	1503	WP_004388312.1	inorganic phosphate transporter PitA	-
CsakCS931_RS17220	3648820..3650010	+	1191	WP_007899945.1	NAD(P)/FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10439.03 Da
• Isoelectric Point: 5.0362

>T97309 WP_007797229.1 NZ_CP027107:c3645508-3645233 [Cronobacter sakazakii]
MLPIQWTEEAKTDLFALISFVASDNPSAAQALLTRIEESILPAAYYPEMFREGRVPDTREIIAHPNYIVVYKVTSEYLLV
LSVLHARQRYP

Nucleotide

• Length: 276 bp

>T97309 NZ_CP027107:c3645508-3645233 [Cronobacter sakazakii]
ATGCTCCCCATTCAATGGACTGAAGAAGCAAAAACGGATCTTTTTGCGCTTATTAGTTTTGTTGCCAGTGATAATCCTTC
CGCCGCGCAGGCGCTGTTAACGCGTATTGAAGAATCAATTTTACCCGCAGCGTACTATCCGGAGATGTTCCGCGAAGGCA
GAGTGCCAGATACGCGTGAAATCATTGCTCACCCGAATTACATCGTCGTTTATAAAGTCACTTCTGAATATCTGCTGGTG
CTGAGCGTTCTGCATGCCCGTCAGCGCTACCCCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7145.21 Da
• Isoelectric Point: 10.4757

>AT97309 WP_076727147.1 NZ_CP027107:c3645699-3645508 [Cronobacter sakazakii]
MPKHDSPGVSSLKTHKQAEQYELWFREKVEAAAASRQPITPHDDVMASARKIIESAKVRRKMA

Nucleotide

• Length: 192 bp

>AT97309 NZ_CP027107:c3645699-3645508 [Cronobacter sakazakii]
ATGCCAAAACATGACTCGCCCGGCGTCTCCAGTCTCAAGACCCATAAACAGGCGGAACAGTACGAGCTGTGGTTTCGTGA
AAAAGTGGAAGCCGCAGCGGCAAGCCGCCAGCCCATTACGCCGCATGACGATGTGATGGCAAGCGCGCGCAAGATCATTG
AGAGCGCAAAAGTGAGGAGAAAAATGGCGTAA

Structures

Toxin

• AlphaFold DB: A0A2S9UG96