Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2376113..2376639 | Replicon | chromosome |
| Accession | NZ_CP027105 | ||
| Organism | Escherichia coli strain RM14721 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | C5097_RS12565 | Protein ID | WP_000323025.1 |
| Coordinates | 2376113..2376400 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | C5097_RS12570 | Protein ID | WP_000534858.1 |
| Coordinates | 2376400..2376639 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C5097_RS12525 | 2371137..2371352 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| C5097_RS25450 | 2371572..2371742 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| C5097_RS12530 | 2372106..2372321 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| C5097_RS12535 | 2372622..2372834 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| C5097_RS25110 | 2372889..2372978 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| C5097_RS12540 | 2373256..2374008 | - | 753 | WP_001047135.1 | antitermination protein | - |
| C5097_RS12545 | 2374022..2375071 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| C5097_RS12550 | 2375073..2375351 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| C5097_RS12555 | 2375418..2375669 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| C5097_RS12560 | 2375886..2376041 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| C5097_RS12565 | 2376113..2376400 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| C5097_RS12570 | 2376400..2376639 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| C5097_RS12575 | 2376664..2376969 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| C5097_RS12580 | 2377172..2377504 | + | 333 | WP_001301033.1 | protein FlxA | - |
| C5097_RS12590 | 2377941..2379254 | - | 1314 | WP_000589005.1 | ISNCY family transposase | - |
| C5097_RS25330 | 2380023..2380310 | - | 288 | Protein_2264 | hypothetical protein | - |
| C5097_RS12605 | 2380921..2381277 | - | 357 | WP_001310834.1 | class I SAM-dependent methyltransferase | - |
| C5097_RS12610 | 2381274..2381375 | - | 102 | Protein_2266 | DUF977 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2321233..2391069 | 69836 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T97272 WP_000323025.1 NZ_CP027105:c2376400-2376113 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T97272 NZ_CP027105:c2376400-2376113 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT97272 WP_000534858.1 NZ_CP027105:c2376639-2376400 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT97272 NZ_CP027105:c2376639-2376400 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|