Detailed information of TA system TA097267

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 439149..439984
• Replicon: chromosome
• Accession: NZ_CP027105
• Organism: Escherichia coli strain RM14721

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: C5097_RS02185
• Protein ID: WP_001487841.1
• Coordinates: 439149..439526 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: C5097_RS02190
• Protein ID: WP_001485190.1
• Coordinates: 439616..439984 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5097_RS02165	436195..437691	-	1497	Protein_369	EAL domain-containing protein	-
C5097_RS02170	437800..438645	-	846	Protein_370	DUF4942 domain-containing protein	-
C5097_RS02175	438730..438927	-	198	WP_085950260.1	DUF957 domain-containing protein	-
C5097_RS02180	438955..439152	-	198	Protein_372	hypothetical protein	-
C5097_RS02185	439149..439526	-	378	WP_001487841.1	TA system toxin CbtA family protein	Toxin
C5097_RS02190	439616..439984	-	369	WP_001485190.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
C5097_RS02195	440034..440678	-	645	WP_001384112.1	hypothetical protein	-
C5097_RS02200	440697..440918	-	222	WP_000692353.1	DUF987 domain-containing protein	-
C5097_RS02205	440987..441463	-	477	WP_001462952.1	RadC family protein	-
C5097_RS02210	441479..441964	-	486	WP_001462967.1	antirestriction protein	-
C5097_RS02215	442056..442874	-	819	WP_001522407.1	DUF945 domain-containing protein	-
C5097_RS02225	442973..443206	-	234	WP_001278282.1	DUF905 family protein	-
C5097_RS02230	443212..443889	-	678	WP_029490458.1	hypothetical protein	-
C5097_RS02235	444008..444892	-	885	WP_001384104.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	426365..450879	24514

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14196.17 Da
• Isoelectric Point: 8.5163

>T97267 WP_001487841.1 NZ_CP027105:c439526-439149 [Escherichia coli]
MKTSPDTHVREASCCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQFINSIDILRARRATGLMTRSHYRTVNNITRGKHPEAKR

Nucleotide

• Length: 378 bp

>T97267 NZ_CP027105:c439526-439149 [Escherichia coli]
ATGAAAACATCACCCGATACACACGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACTCCATTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTCTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTGCGTACCGACCAGCCCGGGTTC
AGCACTTGTCCCCGCTCTCAGTTCATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCAACAGGTCTGATGACCCGCAG
CCACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13690.36 Da
• Isoelectric Point: 5.0696

>AT97267 WP_001485190.1 NZ_CP027105:c439984-439616 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVIPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKT

Nucleotide

• Length: 369 bp

>AT97267 NZ_CP027105:c439984-439616 [Escherichia coli]
GTGTCAGACACACTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGACTGCCGTGCACCGTGAT
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAACGTAA