Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 784538..785195 Replicon chromosome
Accession NZ_CP027064
Organism Klebsiella variicola strain WCHKV030666

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CLQ71_RS05160 Protein ID WP_002916310.1
Coordinates 784785..785195 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CLQ71_RS05155 Protein ID WP_002916312.1
Coordinates 784538..784804 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ71_RS05130 779635..781068 - 1434 WP_012967244.1 6-phospho-beta-glucosidase BglA -
CLQ71_RS05135 781188..781916 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
CLQ71_RS05140 781967..782278 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
CLQ71_RS05145 782442..783101 + 660 WP_008806429.1 hemolysin III family protein -
CLQ71_RS05150 783309..784292 - 984 WP_032733797.1 tRNA-modifying protein YgfZ -
CLQ71_RS05155 784538..784804 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CLQ71_RS05160 784785..785195 + 411 WP_002916310.1 protein YgfX Toxin
CLQ71_RS05165 785202..785723 - 522 WP_008806427.1 flavodoxin FldB -
CLQ71_RS05170 785824..786720 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
CLQ71_RS05175 786743..787456 + 714 WP_064166672.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CLQ71_RS05180 787462..789195 + 1734 WP_064166671.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T97201 WP_002916310.1 NZ_CP027064:784785-785195 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T97201 NZ_CP027064:784785-785195 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT97201 WP_002916312.1 NZ_CP027064:784538-784804 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT97201 NZ_CP027064:784538-784804 [Klebsiella variicola]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References