Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 186535..187178 Replicon plasmid pVir_030666
Accession NZ_CP027063
Organism Klebsiella variicola strain WCHKV030666

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag CLQ71_RS00980 Protein ID WP_023345587.1
Coordinates 186762..187178 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag CLQ71_RS00975 Protein ID WP_023345588.1
Coordinates 186535..186765 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ71_RS00950 182627..183055 - 429 WP_023345594.1 nuclear transport factor 2 family protein -
CLQ71_RS00955 183168..184013 - 846 WP_023345593.1 SDR family oxidoreductase -
CLQ71_RS00960 184116..184511 + 396 WP_023345592.1 helix-turn-helix transcriptional regulator -
CLQ71_RS00965 184623..185207 + 585 WP_023345591.1 TetR/AcrR family transcriptional regulator -
CLQ71_RS00970 185275..186117 + 843 WP_048291887.1 nitroreductase family protein -
CLQ71_RS00975 186535..186765 + 231 WP_023345588.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CLQ71_RS00980 186762..187178 + 417 WP_023345587.1 type II toxin-antitoxin system VapC family toxin Toxin
CLQ71_RS00985 187270..188673 - 1404 WP_023345586.1 glycoside hydrolase family 1 protein -
CLQ71_RS00990 188683..190557 - 1875 WP_048291888.1 beta-glucoside-specific PTS transporter subunit IIABC -
CLQ71_RS00995 190946..191581 - 636 WP_023345584.1 DUF1349 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA / iroN / iroD / iroC / iroB / ybtS / ybtX / ybtQ / ybtP / ybtA / irp2 / irp1 / ybtU / ybtT / ybtE / fyuA 1..236161 236161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15082.55 Da        Isoelectric Point: 7.8644

>T97196 WP_023345587.1 NZ_CP027063:186762-187178 [Klebsiella variicola]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLMLEDWVN

Download         Length: 417 bp

>T97196 NZ_CP027063:186762-187178 [Klebsiella variicola]
ATGAAGAAAACCTGGATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTACGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGATGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCAGCCGGCGCCGTCCTGGTGACGAACAATGTGCGGGAGTTTGAGCGGGTGCCGGGCCTGATGCTGG
AAGACTGGGTGAATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.73 Da        Isoelectric Point: 4.4563

>AT97196 WP_023345588.1 NZ_CP027063:186535-186765 [Klebsiella variicola]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFAP

Download         Length: 231 bp

>AT97196 NZ_CP027063:186535-186765 [Klebsiella variicola]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACATGGGGCTCGTTCGCGCAACTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGCGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References