Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4436936..4437522 Replicon chromosome
Accession NZ_CP027053
Organism Klebsiella pneumoniae strain 2_GR_12

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag A6D68_RS22290 Protein ID WP_002920800.1
Coordinates 4437154..4437522 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag A6D68_RS22285 Protein ID WP_002920802.1
Coordinates 4436936..4437157 (+) Length 74 a.a.

Genomic Context


A6D68_RS22265A6D68_RS22270A6D68_RS22275A6D68_RS22280A6D68_RS22285A6D68_RS22290A6D68_RS22295A6D68_RS22300A6D68_RS22305A6D68_RS22310
Location: 4433093..4434019 (927 bp)
Type: Others
Protein ID: WP_002920807.1
Location: 4434016..4435293 (1278 bp)
Type: Others
Protein ID: WP_002920806.1
Location: 4435290..4436057 (768 bp)
Type: Others
Protein ID: WP_002920803.1
Location: 4436059..4436772 (714 bp)
Type: Others
Protein ID: WP_004145133.1
Location: 4436936..4437157 (222 bp)
Type: Antitoxin
Protein ID: WP_002920802.1
Location: 4437154..4437522 (369 bp)
Type: Toxin
Protein ID: WP_002920800.1
Location: 4437795..4439111 (1317 bp)
Type: Others
Protein ID: WP_002920796.1
Location: 4439218..4440105 (888 bp)
Type: Others
Protein ID: WP_002920792.1
Location: 4440102..4440947 (846 bp)
Type: Others
Protein ID: WP_002920789.1
Location: 4440949..4442019 (1071 bp)
Type: Others
Protein ID: WP_002920787.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A6D68_RS222654433093..4434019+927WP_002920807.1high-affinity branched-chain amino acid ABC transporter permease LivH-
A6D68_RS222704434016..4435293+1278WP_002920806.1branched chain amino acid ABC transporter permease LivM-
A6D68_RS222754435290..4436057+768WP_002920803.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
A6D68_RS222804436059..4436772+714WP_004145133.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
A6D68_RS222854436936..4437157+222WP_002920802.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
A6D68_RS222904437154..4437522+369WP_002920800.1type II toxin-antitoxin system death-on-curing family toxinToxin
A6D68_RS222954437795..4439111+1317WP_002920796.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
A6D68_RS223004439218..4440105+888WP_002920792.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
A6D68_RS223054440102..4440947+846WP_002920789.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
A6D68_RS223104440949..4442019+1071WP_002920787.1sn-glycerol-3-phosphate import ATP-binding protein UgpC-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--4431922..444275610834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-86)

Antitoxin

(1-49)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T97183 WP_002920800.1 NZ_CP027053:4437154-4437522 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T97183 NZ_CP027053:4437154-4437522 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT97183 WP_002920802.1 NZ_CP027053:4436936-4437157 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT97183 NZ_CP027053:4436936-4437157 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GUD1


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GZM4

References