Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3548000..3548516 Replicon chromosome
Accession NZ_CP027053
Organism Klebsiella pneumoniae strain 2_GR_12

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag A6D68_RS17925 Protein ID WP_002886902.1
Coordinates 3548000..3548284 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag A6D68_RS17930 Protein ID WP_002886901.1
Coordinates 3548274..3548516 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6D68_RS17900 3543484..3543792 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
A6D68_RS31785 3543877..3544050 + 174 WP_002886906.1 hypothetical protein -
A6D68_RS17905 3544053..3544796 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
A6D68_RS17915 3545153..3547291 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
A6D68_RS17920 3547532..3547996 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A6D68_RS17925 3548000..3548284 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6D68_RS17930 3548274..3548516 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A6D68_RS17935 3548594..3550504 - 1911 WP_004152270.1 BglG family transcription antiterminator -
A6D68_RS17940 3550527..3551681 - 1155 WP_002886900.1 lactonase family protein -
A6D68_RS17945 3551747..3552487 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T97180 WP_002886902.1 NZ_CP027053:c3548284-3548000 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T97180 NZ_CP027053:c3548284-3548000 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT97180 WP_002886901.1 NZ_CP027053:c3548516-3548274 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT97180 NZ_CP027053:c3548516-3548274 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References