Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3870973..3871592 Replicon chromosome
Accession NZ_CP027042
Organism Klebsiella pneumoniae strain 1_GR_13

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag A6D67_RS19235 Protein ID WP_002892050.1
Coordinates 3871374..3871592 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag A6D67_RS19230 Protein ID WP_002892066.1
Coordinates 3870973..3871347 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6D67_RS19220 3866125..3867318 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A6D67_RS19225 3867341..3870487 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
A6D67_RS19230 3870973..3871347 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
A6D67_RS19235 3871374..3871592 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
A6D67_RS19240 3871755..3872321 + 567 WP_002892030.1 maltose O-acetyltransferase -
A6D67_RS29725 3872293..3872433 - 141 WP_004147370.1 hypothetical protein -
A6D67_RS19245 3872454..3872924 + 471 WP_020802585.1 YlaC family protein -
A6D67_RS19250 3872899..3874350 - 1452 Protein_3712 PLP-dependent aminotransferase family protein -
A6D67_RS19255 3874451..3875149 + 699 WP_023287311.1 GNAT family N-acetyltransferase -
A6D67_RS19260 3875146..3875286 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
A6D67_RS19265 3875286..3875549 - 264 WP_032432663.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T97142 WP_002892050.1 NZ_CP027042:3871374-3871592 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T97142 NZ_CP027042:3871374-3871592 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT97142 WP_002892066.1 NZ_CP027042:3870973-3871347 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT97142 NZ_CP027042:3870973-3871347 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References