Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834298..834955 Replicon chromosome
Accession NZ_CP027042
Organism Klebsiella pneumoniae strain 1_GR_13

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag A6D67_RS04255 Protein ID WP_002916310.1
Coordinates 834545..834955 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag A6D67_RS04250 Protein ID WP_002916312.1
Coordinates 834298..834564 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6D67_RS04225 829454..830887 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
A6D67_RS04230 831006..831734 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
A6D67_RS04235 831784..832095 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
A6D67_RS04240 832259..832918 + 660 WP_002916317.1 hemolysin III family protein -
A6D67_RS04245 833069..834052 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
A6D67_RS04250 834298..834564 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
A6D67_RS04255 834545..834955 + 411 WP_002916310.1 protein YgfX Toxin
A6D67_RS04260 834962..835483 - 522 WP_004144730.1 flavodoxin FldB -
A6D67_RS04265 835584..836480 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
A6D67_RS04270 836503..837216 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A6D67_RS04275 837222..838955 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T97130 WP_002916310.1 NZ_CP027042:834545-834955 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T97130 NZ_CP027042:834545-834955 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT97130 WP_002916312.1 NZ_CP027042:834298-834564 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT97130 NZ_CP027042:834298-834564 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References