Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3789037..3789722 Replicon chromosome
Accession NZ_CP027035
Organism Mycobacterium tuberculosis variant bovis strain 2002/0476

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag C1D11_RS18535 Protein ID WP_003417998.1
Coordinates 3789312..3789722 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag C1D11_RS18530 Protein ID WP_003912220.1
Coordinates 3789037..3789315 (+) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1D11_RS18510 3785026..3786627 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
C1D11_RS18515 3786644..3787348 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
C1D11_RS18520 3787466..3788032 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
C1D11_RS18525 3788094..3788981 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
C1D11_RS18530 3789037..3789315 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C1D11_RS18535 3789312..3789722 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
C1D11_RS18540 3789755..3791491 - 1737 WP_003418002.1 cholesterol oxidase -
C1D11_RS18545 3791547..3792674 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
C1D11_RS18550 3792694..3794283 - 1590 WP_105577783.1 IMP dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-118)

Antitoxin

(3-54)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T97108 WP_003417998.1 NZ_CP027035:3789312-3789722 [Mycobacterium tuberculosis variant bovis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T97108 NZ_CP027035:3789312-3789722 [Mycobacterium tuberculosis variant bovis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT97108 WP_003912220.1 NZ_CP027035:3789037-3789315 [Mycobacterium tuberculosis variant bovis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp

>AT97108 NZ_CP027035:3789037-3789315 [Mycobacterium tuberculosis variant bovis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TIR9


Antitoxin

Source ID Structure

References