Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3734826..3735355 Replicon chromosome
Accession NZ_CP027035
Organism Mycobacterium tuberculosis variant bovis strain 2002/0476

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag C1D11_RS18295 Protein ID WP_003417760.1
Coordinates 3735098..3735355 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag C1D11_RS18290 Protein ID WP_003417757.1
Coordinates 3734826..3735101 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1D11_RS18250 3729851..3731155 - 1305 WP_010950875.1 PPE family protein -
C1D11_RS21715 3731624..3733061 - 1438 Protein_3423 FAD-binding oxidoreductase -
C1D11_RS18275 3733164..3733553 + 390 WP_010950876.1 DUF732 domain-containing protein -
C1D11_RS18280 3733567..3733860 - 294 WP_003417749.1 DUF3017 domain-containing protein -
C1D11_RS18285 3733857..3734702 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
C1D11_RS18290 3734826..3735101 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
C1D11_RS18295 3735098..3735355 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
C1D11_RS18300 3735397..3736587 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
C1D11_RS18305 3736704..3737072 + 369 WP_003417765.1 FHA domain-containing protein -
C1D11_RS18310 3737069..3737620 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
C1D11_RS18315 3737627..3738208 - 582 WP_003417769.1 ATP/GTP-binding protein -
C1D11_RS18320 3738189..3738557 - 369 WP_003417772.1 DUF742 domain-containing protein -
C1D11_RS18325 3738535..3738927 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T97106 WP_003417760.1 NZ_CP027035:3735098-3735355 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T97106 NZ_CP027035:3735098-3735355 [Mycobacterium tuberculosis variant bovis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT97106 WP_003417757.1 NZ_CP027035:3734826-3735101 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT97106 NZ_CP027035:3734826-3735101 [Mycobacterium tuberculosis variant bovis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References