Detailed information of TA system TA097105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3672742..3673416
• Replicon: chromosome
• Accession: NZ_CP027035
• Organism: Mycobacterium tuberculosis variant bovis strain 2002/0476

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF52
• Locus tag: C1D11_RS18060
• Protein ID: WP_003417282.1
• Coordinates: 3672742..3673170 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: C1D11_RS18065
• Protein ID: WP_003417286.1
• Coordinates: 3673174..3673416 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1D11_RS18035	3668564..3668965	-	402	WP_003417264.1	cytidine deaminase	-
C1D11_RS18040	3669106..3669540	+	435	WP_003900017.1	succinate dehydrogenase, cytochrome b556 subunit	-
C1D11_RS18045	3669537..3669971	+	435	WP_003417269.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
C1D11_RS18050	3670100..3671872	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
C1D11_RS18055	3671872..3672663	+	792	WP_010950870.1	succinate dehydrogenase iron-sulfur subunit	-
C1D11_RS18060	3672742..3673170	-	429	WP_003417282.1	type II toxin-antitoxin system VapC family toxin	Toxin
C1D11_RS18065	3673174..3673416	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
C1D11_RS18070	3673538..3674152	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
C1D11_RS18075	3674149..3674814	-	666	WP_003417290.1	molybdopterin converting factor subunit 1	-
C1D11_RS18080	3674815..3675348	-	534	WP_003417293.1	cyclic pyranopterin monophosphate synthase MoaC	-
C1D11_RS18085	3675345..3675719	-	375	WP_003417295.1	4a-hydroxytetrahydrobiopterin dehydratase	-
C1D11_RS18090	3675816..3676880	-	1065	WP_003913037.1	GTP 3',8-cyclase MoaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15834.16 Da
• Isoelectric Point: 8.5471

>T97105 WP_003417282.1 NZ_CP027035:c3673170-3672742 [Mycobacterium tuberculosis variant bovis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T97105 NZ_CP027035:c3673170-3672742 [Mycobacterium tuberculosis variant bovis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT97105 WP_003417286.1 NZ_CP027035:c3673416-3673174 [Mycobacterium tuberculosis variant bovis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT97105 NZ_CP027035:c3673416-3673174 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• AlphaFold DB: A0A7U4FBL0

Antitoxin

• AlphaFold DB: G0TI59