Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2907050..2907764 Replicon chromosome
Accession NZ_CP027035
Organism Mycobacterium tuberculosis variant bovis strain 2002/0476

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag C1D11_RS14195 Protein ID WP_003413460.1
Coordinates 2907324..2907764 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag C1D11_RS14190 Protein ID WP_003413456.1
Coordinates 2907050..2907337 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1D11_RS14155 2902472..2902717 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
C1D11_RS14160 2902714..2903118 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
C1D11_RS14165 2903335..2903955 + 621 WP_003413441.1 DUF4178 domain-containing protein -
C1D11_RS14170 2903966..2904460 + 495 WP_003413444.1 DUF2617 family protein -
C1D11_RS14175 2904457..2904888 + 432 WP_003413445.1 DUF4247 domain-containing protein -
C1D11_RS14180 2904913..2905371 + 459 WP_003413451.1 DUF350 domain-containing protein -
C1D11_RS14185 2905368..2906939 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
C1D11_RS14190 2907050..2907337 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
C1D11_RS14195 2907324..2907764 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
C1D11_RS14200 2907785..2908540 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
C1D11_RS14205 2908673..2909269 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
C1D11_RS14210 2909277..2910122 - 846 WP_010950749.1 acyl-CoA thioesterase II -
C1D11_RS14215 2910151..2911050 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
C1D11_RS14220 2911178..2911852 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T97096 WP_003413460.1 NZ_CP027035:2907324-2907764 [Mycobacterium tuberculosis variant bovis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T97096 NZ_CP027035:2907324-2907764 [Mycobacterium tuberculosis variant bovis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT97096 WP_003413456.1 NZ_CP027035:2907050-2907337 [Mycobacterium tuberculosis variant bovis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT97096 NZ_CP027035:2907050-2907337 [Mycobacterium tuberculosis variant bovis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References