Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2846709..2847346 Replicon chromosome
Accession NZ_CP027035
Organism Mycobacterium tuberculosis variant bovis strain 2002/0476

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag C1D11_RS13905 Protein ID WP_003413180.1
Coordinates 2846709..2847104 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag C1D11_RS13910 Protein ID WP_003413183.1
Coordinates 2847101..2847346 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1D11_RS13865 2842794..2843453 + 660 WP_105577761.1 LppA family lipoprotein -
C1D11_RS13870 2843450..2844109 + 660 WP_003900847.1 hypothetical protein -
C1D11_RS13875 2844106..2844768 + 663 WP_003900848.1 hypothetical protein -
C1D11_RS13880 2844765..2845043 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
C1D11_RS13885 2845136..2845549 + 414 WP_003413164.1 PIN domain nuclease -
C1D11_RS13890 2845588..2845845 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein -
C1D11_RS13895 2845842..2846219 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
C1D11_RS13900 2846235..2846609 - 375 WP_003413177.1 hypothetical protein -
C1D11_RS13905 2846709..2847104 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
C1D11_RS13910 2847101..2847346 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
C1D11_RS13920 2847757..2848176 - 420 WP_003413190.1 A24 family peptidase -
C1D11_RS13925 2848188..2849015 - 828 WP_010950736.1 shikimate dehydrogenase -
C1D11_RS13930 2848993..2850246 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
C1D11_RS13935 2850239..2850751 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T97095 WP_003413180.1 NZ_CP027035:c2847104-2846709 [Mycobacterium tuberculosis variant bovis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T97095 NZ_CP027035:c2847104-2846709 [Mycobacterium tuberculosis variant bovis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT97095 WP_003413183.1 NZ_CP027035:c2847346-2847101 [Mycobacterium tuberculosis variant bovis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT97095 NZ_CP027035:c2847346-2847101 [Mycobacterium tuberculosis variant bovis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References