Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2392356..2392885 Replicon chromosome
Accession NZ_CP027035
Organism Mycobacterium tuberculosis variant bovis strain 2002/0476

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag C1D11_RS11635 Protein ID WP_003411124.1
Coordinates 2392356..2392673 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag C1D11_RS11640 Protein ID WP_003411127.1
Coordinates 2392670..2392885 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1D11_RS11605 2387377..2388453 + 1077 WP_003411110.1 hypothetical protein -
C1D11_RS11610 2388450..2388731 + 282 WP_003411112.1 hypothetical protein -
C1D11_RS11615 2388767..2389840 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
C1D11_RS11620 2389845..2390375 - 531 WP_050008806.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
C1D11_RS11625 2390423..2391769 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
C1D11_RS11635 2392356..2392673 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1D11_RS11640 2392670..2392885 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
C1D11_RS11645 2393140..2394198 + 1059 WP_003411129.1 hypothetical protein -
C1D11_RS11650 2394328..2394684 - 357 WP_003411130.1 hypothetical protein -
C1D11_RS11655 2394779..2395561 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
C1D11_RS11660 2395829..2396119 - 291 WP_003900476.1 YggT family protein -
C1D11_RS11665 2396281..2396937 - 657 WP_044290799.1 cell division protein SepF -
C1D11_RS11670 2397003..2397779 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T97090 WP_003411124.1 NZ_CP027035:c2392673-2392356 [Mycobacterium tuberculosis variant bovis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T97090 NZ_CP027035:c2392673-2392356 [Mycobacterium tuberculosis variant bovis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT97090 WP_003411127.1 NZ_CP027035:c2392885-2392670 [Mycobacterium tuberculosis variant bovis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT97090 NZ_CP027035:c2392885-2392670 [Mycobacterium tuberculosis variant bovis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References