Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-RHH |
Location | 2204944..2205488 | Replicon | chromosome |
Accession | NZ_CP027035 | ||
Organism | Mycobacterium tuberculosis variant bovis strain 2002/0476 |
Toxin (Protein)
Gene name | parE | Uniprot ID | G0TLU9 |
Locus tag | C1D11_RS10700 | Protein ID | WP_003409896.1 |
Coordinates | 2204944..2205240 (-) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P67299 |
Locus tag | C1D11_RS10705 | Protein ID | WP_003409899.1 |
Coordinates | 2205237..2205488 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C1D11_RS10645 | 2199977..2200327 | - | 351 | WP_003409871.1 | hypothetical protein | - |
C1D11_RS10650 | 2200338..2201240 | - | 903 | WP_003409874.1 | hypothetical protein | - |
C1D11_RS10655 | 2201261..2201452 | - | 192 | WP_003409876.1 | hypothetical protein | - |
C1D11_RS10660 | 2201453..2201749 | - | 297 | WP_003409877.1 | hypothetical protein | - |
C1D11_RS10665 | 2201989..2202204 | + | 216 | WP_003409878.1 | antitoxin | - |
C1D11_RS10670 | 2202201..2202512 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
C1D11_RS21595 | 2202486..2203007 | - | 522 | WP_010950637.1 | hypothetical protein | - |
C1D11_RS10680 | 2202982..2203359 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
C1D11_RS10685 | 2203401..2203850 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
C1D11_RS10690 | 2203847..2204392 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
C1D11_RS10695 | 2204281..2204895 | - | 615 | WP_003901296.1 | hypothetical protein | - |
C1D11_RS10700 | 2204944..2205240 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
C1D11_RS10705 | 2205237..2205488 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
C1D11_RS10710 | 2205475..2205969 | + | 495 | WP_003899099.1 | hypothetical protein | - |
C1D11_RS10715 | 2206129..2206536 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
C1D11_RS10720 | 2206540..2206812 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
C1D11_RS10725 | 2206845..2208065 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
C1D11_RS10740 | 2208952..2209368 | + | 417 | WP_162014414.1 | hypothetical protein | - |
C1D11_RS10745 | 2209453..2210301 | + | 849 | WP_003409942.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T97082 WP_003409896.1 NZ_CP027035:c2205240-2204944 [Mycobacterium tuberculosis variant bovis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T97082 NZ_CP027035:c2205240-2204944 [Mycobacterium tuberculosis variant bovis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT97082 WP_003409899.1 NZ_CP027035:c2205488-2205237 [Mycobacterium tuberculosis variant bovis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT97082 NZ_CP027035:c2205488-2205237 [Mycobacterium tuberculosis variant bovis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TLU9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BUZ2 |