Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1940965..1941578 Replicon chromosome
Accession NZ_CP027035
Organism Mycobacterium tuberculosis variant bovis strain 2002/0476

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag C1D11_RS09395 Protein ID WP_003408465.1
Coordinates 1940965..1941354 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag C1D11_RS09400 Protein ID WP_003408469.1
Coordinates 1941351..1941578 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1D11_RS09365 1936595..1937509 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
C1D11_RS09370 1937512..1938342 + 831 WP_003408448.1 cyclase family protein -
C1D11_RS09375 1938342..1938692 + 351 WP_003898986.1 cupin domain-containing protein -
C1D11_RS09380 1938745..1939562 + 818 Protein_1761 3-keto-5-aminohexanoate cleavage protein -
C1D11_RS09385 1939576..1940355 + 780 WP_003408460.1 IclR family transcriptional regulator -
C1D11_RS09395 1940965..1941354 - 390 WP_003408465.1 PIN domain-containing protein Toxin
C1D11_RS09400 1941351..1941578 - 228 WP_003408469.1 antitoxin Antitoxin
C1D11_RS09405 1941796..1943280 + 1485 WP_010950580.1 biotin carboxylase -
C1D11_RS09410 1943277..1944524 + 1248 WP_055381120.1 serine hydrolase -
C1D11_RS09415 1944567..1944746 - 180 Protein_1767 hypothetical protein -
C1D11_RS09420 1944795..1946056 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
C1D11_RS09425 1946099..1946344 - 246 Protein_1769 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T97078 WP_003408465.1 NZ_CP027035:c1941354-1940965 [Mycobacterium tuberculosis variant bovis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T97078 NZ_CP027035:c1941354-1940965 [Mycobacterium tuberculosis variant bovis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT97078 WP_003408469.1 NZ_CP027035:c1941578-1941351 [Mycobacterium tuberculosis variant bovis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT97078 NZ_CP027035:c1941578-1941351 [Mycobacterium tuberculosis variant bovis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References