Detailed information of TA system TA097072

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1385408..1386096
• Replicon: chromosome
• Accession: NZ_CP027035
• Organism: Mycobacterium tuberculosis variant bovis strain 2002/0476

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: C1D11_RS06865
• Protein ID: WP_003406304.1
• Coordinates: 1385665..1386096 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: C1D11_RS06860
• Protein ID: WP_003406302.1
• Coordinates: 1385408..1385668 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1D11_RS06840	1380985..1381809	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
C1D11_RS06845	1381814..1382995	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
C1D11_RS06850	1383072..1384172	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
C1D11_RS06855	1384343..1385332	+	990	WP_003406301.1	malate dehydrogenase	-
C1D11_RS06860	1385408..1385668	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
C1D11_RS06865	1385665..1386096	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
C1D11_RS06870	1386119..1387807	-	1689	WP_003910308.1	PE family protein	-
C1D11_RS06880	1387987..1388847	+	861	WP_003406306.1	hypothetical protein	-
C1D11_RS06885	1388928..1389758	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
C1D11_RS06890	1389815..1390108	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
C1D11_RS06895	1390105..1390374	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T97072 WP_003406304.1 NZ_CP027035:1385665-1386096 [Mycobacterium tuberculosis variant bovis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T97072 NZ_CP027035:1385665-1386096 [Mycobacterium tuberculosis variant bovis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT97072 WP_003406302.1 NZ_CP027035:1385408-1385668 [Mycobacterium tuberculosis variant bovis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT97072 NZ_CP027035:1385408-1385668 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6