Detailed information of TA system TA097071

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1240604..1241172
• Replicon: chromosome
• Accession: NZ_CP027035
• Organism: Mycobacterium tuberculosis variant bovis strain 2002/0476

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TH08
• Locus tag: C1D11_RS06165
• Protein ID: WP_003405865.1
• Coordinates: 1240798..1241172 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TH07
• Locus tag: C1D11_RS06160
• Protein ID: WP_003405863.1
• Coordinates: 1240604..1240801 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1D11_RS06140	1236645..1237283	-	639	WP_105577721.1	lipid droplet-associated protein	-
C1D11_RS06145	1237373..1238380	+	1008	WP_003405853.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
C1D11_RS06150	1238397..1239380	-	984	WP_003898731.1	hypothetical protein	-
C1D11_RS06155	1239443..1240516	+	1074	WP_003405860.1	redox-regulated ATPase YchF	-
C1D11_RS06160	1240604..1240801	+	198	WP_003405863.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
C1D11_RS06165	1240798..1241172	+	375	WP_003405865.1	type II toxin-antitoxin system VapC family toxin	Toxin
C1D11_RS06170	1241375..1242073	+	699	WP_010950494.1	hypothetical protein	-
C1D11_RS06175	1242191..1242376	+	186	WP_003901093.1	hypothetical protein	-
C1D11_RS06180	1242303..1242578	-	276	WP_003405867.1	hypothetical protein	-
C1D11_RS06185	1242821..1243144	+	324	WP_003405871.1	antibiotic biosynthesis monooxygenase	-
C1D11_RS06190	1243159..1243869	-	711	WP_003911399.1	hypothetical protein	-
C1D11_RS21510	1243891..1244100	+	210	WP_181146645.1	hypothetical protein	-
C1D11_RS06195	1244052..1244759	-	708	Protein_1161	adenylate/guanylate cyclase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13444.56 Da
• Isoelectric Point: 5.1881

>T97071 WP_003405865.1 NZ_CP027035:1240798-1241172 [Mycobacterium tuberculosis variant bovis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Nucleotide

• Length: 375 bp

>T97071 NZ_CP027035:1240798-1241172 [Mycobacterium tuberculosis variant bovis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 6973.03 Da
• Isoelectric Point: 11.7327

>AT97071 WP_003405863.1 NZ_CP027035:1240604-1240801 [Mycobacterium tuberculosis variant bovis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Nucleotide

• Length: 198 bp

>AT97071 NZ_CP027035:1240604-1240801 [Mycobacterium tuberculosis variant bovis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0TH08

Antitoxin

• AlphaFold DB: G0TH07