Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1231848..1232479 Replicon chromosome
Accession NZ_CP027035
Organism Mycobacterium tuberculosis variant bovis strain 2002/0476

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag C1D11_RS06110 Protein ID WP_003405820.1
Coordinates 1231848..1232159 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag C1D11_RS06115 Protein ID WP_003405836.1
Coordinates 1232159..1232479 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1D11_RS06090 1227330..1228754 - 1425 WP_003405805.1 class II fumarate hydratase -
C1D11_RS06095 1228785..1229873 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
C1D11_RS06100 1229929..1230573 + 645 WP_003915494.1 DUF4245 domain-containing protein -
C1D11_RS06105 1230580..1231736 - 1157 Protein_1142 AI-2E family transporter -
C1D11_RS06110 1231848..1232159 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
C1D11_RS06115 1232159..1232479 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
C1D11_RS06120 1232489..1234014 + 1526 Protein_1145 carboxylesterase/lipase family protein -
C1D11_RS06125 1234032..1235144 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
C1D11_RS06130 1235154..1235411 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
C1D11_RS06135 1235401..1236648 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
C1D11_RS06140 1236645..1237283 - 639 WP_105577721.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T97070 WP_003405820.1 NZ_CP027035:c1232159-1231848 [Mycobacterium tuberculosis variant bovis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T97070 NZ_CP027035:c1232159-1231848 [Mycobacterium tuberculosis variant bovis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT97070 WP_003405836.1 NZ_CP027035:c1232479-1232159 [Mycobacterium tuberculosis variant bovis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT97070 NZ_CP027035:c1232479-1232159 [Mycobacterium tuberculosis variant bovis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References