Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 704016..704659 Replicon chromosome
Accession NZ_CP027035
Organism Mycobacterium tuberculosis variant bovis strain 2002/0476

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag C1D11_RS03285 Protein ID WP_003403187.1
Coordinates 704258..704659 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag C1D11_RS03280 Protein ID WP_003403184.1
Coordinates 704016..704261 (+) Length 82 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1D11_RS03245 699296..699766 - 471 WP_003403144.1 HAMP domain-containing protein -
C1D11_RS03250 699810..700571 - 762 WP_010950420.1 two-component system response regulator TcrA -
C1D11_RS03255 700628..700939 + 312 WP_003403164.1 hypothetical protein -
C1D11_RS03260 701011..701961 + 951 WP_003907436.1 DUF1259 domain-containing protein -
C1D11_RS03265 702202..702786 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
C1D11_RS03270 702788..703498 + 711 Protein_626 transposase -
C1D11_RS03275 703501..703971 + 471 WP_003898523.1 hypothetical protein -
C1D11_RS03280 704016..704261 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C1D11_RS03285 704258..704659 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
C1D11_RS21310 705047..705214 - 168 WP_077385191.1 DUF3800 domain-containing protein -
C1D11_RS03300 705247..705444 - 198 WP_003403191.1 hypothetical protein -
C1D11_RS03305 705524..706681 - 1158 WP_003403193.1 hypothetical protein -
C1D11_RS03310 706733..706954 - 222 WP_003898525.1 DUF4926 domain-containing protein -
C1D11_RS03315 707096..707701 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-124)

Antitoxin

(1-80)


Sequences


Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T97058 WP_003403187.1 NZ_CP027035:704258-704659 [Mycobacterium tuberculosis variant bovis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T97058 NZ_CP027035:704258-704659 [Mycobacterium tuberculosis variant bovis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT97058 WP_003403184.1 NZ_CP027035:704016-704261 [Mycobacterium tuberculosis variant bovis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT97058 NZ_CP027035:704016-704261 [Mycobacterium tuberculosis variant bovis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6


Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References