Detailed information of TA system TA097047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 195030..195589
• Replicon: chromosome
• Accession: NZ_CP027031
• Organism: Vibrio vulnificus strain FORC_077

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FORC77_RS16610
• Protein ID: WP_047111817.1
• Coordinates: 195311..195589 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3Q0L0M2
• Locus tag: FORC77_RS16605
• Protein ID: WP_011082348.1
• Coordinates: 195030..195314 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC77_RS16575	190126..191319	+	1194	WP_011082341.1	glycine C-acetyltransferase	-
FORC77_RS16580	191399..192430	+	1032	WP_131070228.1	L-threonine 3-dehydrogenase	-
FORC77_RS16585	192510..193010	-	501	WP_065090958.1	hypothetical protein	-
FORC77_RS16590	193088..193351	-	264	WP_011082346.1	hypothetical protein	-
FORC77_RS16595	193536..194069	-	534	WP_088428331.1	hypothetical protein	-
FORC77_RS16600	194204..194812	-	609	WP_011151714.1	hypothetical protein	-
FORC77_RS16605	195030..195314	+	285	WP_011082348.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FORC77_RS16610	195311..195589	+	279	WP_047111817.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FORC77_RS23620	195618..195677	-	60	WP_081280400.1	DUF3265 domain-containing protein	-
FORC77_RS16620	195737..197521	-	1785	WP_065090960.1	NACHT domain-containing protein	-
FORC77_RS16625	197566..197667	-	102	WP_081280401.1	DUF3265 domain-containing protein	-
FORC77_RS16630	197685..198245	-	561	WP_065090961.1	hypothetical protein	-
FORC77_RS16635	199298..199813	-	516	WP_072610557.1	lipocalin family protein	-
FORC77_RS16640	199929..200552	-	624	WP_015727543.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	194204..198245	4041

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-45)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10951.63 Da
• Isoelectric Point: 4.3430

>T97047 WP_047111817.1 NZ_CP027031:195311-195589 [Vibrio vulnificus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIETKVENLLEQPLMGVQRDSIRGRLLIIPEISMVISYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T97047 NZ_CP027031:195311-195589 [Vibrio vulnificus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAACAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATAGCA
TCCGCGGTCGATTACTCATTATTCCCGAGATTTCGATGGTTATCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTCCTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11083.43 Da
• Isoelectric Point: 9.2167

>AT97047 WP_011082348.1 NZ_CP027031:195030-195314 [Vibrio vulnificus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT97047 NZ_CP027031:195030-195314 [Vibrio vulnificus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCAGAGAGTCAAGGTCGCAC
TCTTAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCATTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGGGGTAAGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q0L0M2