Detailed information of TA system TA097045

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1527287..1527852
• Replicon: chromosome
• Accession: NZ_CP027030
• Organism: Vibrio vulnificus strain FORC_077

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I3NI62
• Locus tag: FORC77_RS07765
• Protein ID: WP_011080400.1
• Coordinates: 1527565..1527852 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3NI65
• Locus tag: FORC77_RS07760
• Protein ID: WP_011080399.1
• Coordinates: 1527287..1527568 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC77_RS07705	1522566..1522688	+	123	WP_131070170.1	DUF3265 domain-containing protein	-
FORC77_RS07710	1522717..1523184	+	468	WP_131069837.1	GNAT family N-acetyltransferase	-
FORC77_RS23605	1523213..1523291	+	79	Protein_1419	DUF3265 domain-containing protein	-
FORC77_RS07720	1523301..1523756	+	456	WP_011080395.1	GNAT family N-acetyltransferase	-
FORC77_RS07725	1523902..1524399	+	498	WP_131069839.1	hypothetical protein	-
FORC77_RS07735	1524554..1525342	+	789	WP_011080396.1	hypothetical protein	-
FORC77_RS07740	1525667..1525996	+	330	WP_011080397.1	hypothetical protein	-
FORC77_RS07745	1526011..1526103	+	93	WP_005377014.1	DUF3265 domain-containing protein	-
FORC77_RS07750	1526139..1526618	+	480	WP_011080398.1	GNAT family N-acetyltransferase	-
FORC77_RS07755	1526600..1526743	+	144	WP_080553518.1	DUF3265 domain-containing protein	-
FORC77_RS07760	1527287..1527568	+	282	WP_011080399.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FORC77_RS07765	1527565..1527852	+	288	WP_011080400.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC77_RS07770	1528040..1528789	+	750	WP_207308098.1	hypothetical protein	-
FORC77_RS07775	1528815..1528904	+	90	WP_080933288.1	DUF3265 domain-containing protein	-
FORC77_RS07780	1528928..1529242	+	315	WP_207308099.1	hypothetical protein	-
FORC77_RS07785	1529269..1529361	+	93	WP_079857208.1	DUF3265 domain-containing protein	-
FORC77_RS07790	1529405..1529659	+	255	WP_131069841.1	hypothetical protein	-
FORC77_RS07795	1529656..1529817	+	162	Protein_1434	DUF3265 domain-containing protein	-
FORC77_RS07800	1529795..1530304	+	510	WP_131069842.1	ClbS/DfsB family four-helix bundle protein	-
FORC77_RS07805	1530295..1530411	+	117	WP_131070171.1	DUF3265 domain-containing protein	-
FORC77_RS07810	1530439..1530972	+	534	WP_131069843.1	hypothetical protein	-
FORC77_RS07815	1530998..1531090	+	93	WP_207308100.1	DUF3265 domain-containing protein	-
FORC77_RS23610	1531538..1531676	+	139	Protein_1439	DUF3265 domain-containing protein	-
FORC77_RS07825	1531698..1532489	+	792	WP_207308109.1	PhzF family phenazine biosynthesis isomerase	-
FORC77_RS07830	1532504..1532644	+	141	WP_131070173.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1411980..1556552	144572
	-	inside	Integron	-	-	1485225..1551656	66431

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10991.69 Da
• Isoelectric Point: 5.0872

>T97045 WP_011080400.1 NZ_CP027030:1527565-1527852 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFISLDNPVAAESWVNEVFDKTELLSNMPEMGRMVPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQMLTESDV

Nucleotide

• Length: 288 bp

>T97045 NZ_CP027030:1527565-1527852 [Vibrio vulnificus]
ATGAAAGTAGTCTGGTCACCACTAGCATTACAAAAGTTAGGTGATGCAGCCGAGTTTATTTCACTGGATAACCCAGTGGC
AGCAGAAAGCTGGGTTAATGAGGTTTTCGATAAAACCGAACTTCTCTCAAATATGCCTGAAATGGGGCGAATGGTTCCTG
AGTTACCTCATACTAATTATCGTGAAATCCTTTTTGGCCACTACCGAATCATATATAGCCTCAGTCATGAAATTCGTGTC
CTGACAGTAAGAAATTGTCGTCAAATGCTAACGGAAAGTGATGTGTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10426.96 Da
• Isoelectric Point: 5.8719

>AT97045 WP_011080399.1 NZ_CP027030:1527287-1527568 [Vibrio vulnificus]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT97045 NZ_CP027030:1527287-1527568 [Vibrio vulnificus]
ATGAGCCGTATCCACTTTGACCAAGATATTCAGCCTTTGTCTGAATTTCGTGCTGGCGTAACGTCATTTATTAAACAGAT
TAACGAAACTCGTAGACCATTAGTAATCACACAACGTGGTAAGGGTGTTGCGGTTGTCCTTGATGTTGCGGAATATGAAG
CAATGCAGGAGAAGATCGAGTTACTGGAAGAAATGCGTACTGCTGAAGCACAATTAGCTTCAGGTTTAGGTGTTTCCAAT
GAAGACGCTCGCGCTCAAGTGTTGGGGCGTATTAAGAAATGA

Structures

Toxin

• AlphaFold DB: A0A3Q0L634

Antitoxin

• AlphaFold DB: A0A3S0MQY5