Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 1527287..1527852 Replicon chromosome
Accession NZ_CP027030
Organism Vibrio vulnificus strain FORC_077

Toxin (Protein)


Gene name relE Uniprot ID I3NI62
Locus tag FORC77_RS07765 Protein ID WP_011080400.1
Coordinates 1527565..1527852 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3NI65
Locus tag FORC77_RS07760 Protein ID WP_011080399.1
Coordinates 1527287..1527568 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC77_RS07705 1522566..1522688 + 123 WP_131070170.1 DUF3265 domain-containing protein -
FORC77_RS07710 1522717..1523184 + 468 WP_131069837.1 GNAT family N-acetyltransferase -
FORC77_RS23605 1523213..1523291 + 79 Protein_1419 DUF3265 domain-containing protein -
FORC77_RS07720 1523301..1523756 + 456 WP_011080395.1 GNAT family N-acetyltransferase -
FORC77_RS07725 1523902..1524399 + 498 WP_131069839.1 hypothetical protein -
FORC77_RS07735 1524554..1525342 + 789 WP_011080396.1 hypothetical protein -
FORC77_RS07740 1525667..1525996 + 330 WP_011080397.1 hypothetical protein -
FORC77_RS07745 1526011..1526103 + 93 WP_005377014.1 DUF3265 domain-containing protein -
FORC77_RS07750 1526139..1526618 + 480 WP_011080398.1 GNAT family N-acetyltransferase -
FORC77_RS07755 1526600..1526743 + 144 WP_080553518.1 DUF3265 domain-containing protein -
FORC77_RS07760 1527287..1527568 + 282 WP_011080399.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC77_RS07765 1527565..1527852 + 288 WP_011080400.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC77_RS07770 1528040..1528789 + 750 WP_207308098.1 hypothetical protein -
FORC77_RS07775 1528815..1528904 + 90 WP_080933288.1 DUF3265 domain-containing protein -
FORC77_RS07780 1528928..1529242 + 315 WP_207308099.1 hypothetical protein -
FORC77_RS07785 1529269..1529361 + 93 WP_079857208.1 DUF3265 domain-containing protein -
FORC77_RS07790 1529405..1529659 + 255 WP_131069841.1 hypothetical protein -
FORC77_RS07795 1529656..1529817 + 162 Protein_1434 DUF3265 domain-containing protein -
FORC77_RS07800 1529795..1530304 + 510 WP_131069842.1 ClbS/DfsB family four-helix bundle protein -
FORC77_RS07805 1530295..1530411 + 117 WP_131070171.1 DUF3265 domain-containing protein -
FORC77_RS07810 1530439..1530972 + 534 WP_131069843.1 hypothetical protein -
FORC77_RS07815 1530998..1531090 + 93 WP_207308100.1 DUF3265 domain-containing protein -
FORC77_RS23610 1531538..1531676 + 139 Protein_1439 DUF3265 domain-containing protein -
FORC77_RS07825 1531698..1532489 + 792 WP_207308109.1 PhzF family phenazine biosynthesis isomerase -
FORC77_RS07830 1532504..1532644 + 141 WP_131070173.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1411980..1556552 144572
- inside Integron - - 1485225..1551656 66431


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.69 Da        Isoelectric Point: 5.0872

>T97045 WP_011080400.1 NZ_CP027030:1527565-1527852 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFISLDNPVAAESWVNEVFDKTELLSNMPEMGRMVPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQMLTESDV

Download         Length: 288 bp

>T97045 NZ_CP027030:1527565-1527852 [Vibrio vulnificus]
ATGAAAGTAGTCTGGTCACCACTAGCATTACAAAAGTTAGGTGATGCAGCCGAGTTTATTTCACTGGATAACCCAGTGGC
AGCAGAAAGCTGGGTTAATGAGGTTTTCGATAAAACCGAACTTCTCTCAAATATGCCTGAAATGGGGCGAATGGTTCCTG
AGTTACCTCATACTAATTATCGTGAAATCCTTTTTGGCCACTACCGAATCATATATAGCCTCAGTCATGAAATTCGTGTC
CTGACAGTAAGAAATTGTCGTCAAATGCTAACGGAAAGTGATGTGTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10426.96 Da        Isoelectric Point: 5.8719

>AT97045 WP_011080399.1 NZ_CP027030:1527287-1527568 [Vibrio vulnificus]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK

Download         Length: 282 bp

>AT97045 NZ_CP027030:1527287-1527568 [Vibrio vulnificus]
ATGAGCCGTATCCACTTTGACCAAGATATTCAGCCTTTGTCTGAATTTCGTGCTGGCGTAACGTCATTTATTAAACAGAT
TAACGAAACTCGTAGACCATTAGTAATCACACAACGTGGTAAGGGTGTTGCGGTTGTCCTTGATGTTGCGGAATATGAAG
CAATGCAGGAGAAGATCGAGTTACTGGAAGAAATGCGTACTGCTGAAGCACAATTAGCTTCAGGTTTAGGTGTTTCCAAT
GAAGACGCTCGCGCTCAAGTGTTGGGGCGTATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L634

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0MQY5

References