97044

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1476344..1476882 Replicon chromosome
Accession NZ_CP027030
Organism Vibrio vulnificus strain FORC_077

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag FORC77_RS07165 Protein ID WP_001247271.1
Coordinates 1476344..1476643 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag FORC77_RS07170 Protein ID WP_011080384.1
Coordinates 1476640..1476882 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC77_RS23440 1471711..1472019 + 309 WP_165387000.1 hypothetical protein -
FORC77_RS07110 1472488..1472619 + 132 Protein_1314 DUF3265 domain-containing protein -
FORC77_RS07115 1472625..1473167 + 543 WP_101957068.1 hypothetical protein -
FORC77_RS07120 1473190..1473282 + 93 Protein_1316 DUF3265 domain-containing protein -
FORC77_RS07125 1473642..1473764 + 123 WP_131070144.1 DUF3265 domain-containing protein -
FORC77_RS07130 1474211..1474303 + 93 WP_079748816.1 DUF3265 domain-containing protein -
FORC77_RS07135 1474332..1474793 + 462 WP_165480069.1 GNAT family N-acetyltransferase -
FORC77_RS07150 1475235..1475444 + 210 WP_131070145.1 DUF3265 domain-containing protein -
FORC77_RS07155 1475512..1476027 + 516 WP_072615229.1 type VI secretion system amidase effector protein Tae4 -
FORC77_RS07165 1476344..1476643 - 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC77_RS07170 1476640..1476882 - 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FORC77_RS07175 1476947..1477087 + 141 WP_131070146.1 DUF3265 domain-containing protein -
FORC77_RS07180 1477226..1478434 + 1209 WP_103277394.1 site-specific integrase -
FORC77_RS07185 1478709..1478945 + 237 WP_011080322.1 helix-turn-helix domain-containing protein -
FORC77_RS07190 1478938..1479186 + 249 WP_131069810.1 hypothetical protein -
FORC77_RS07195 1479186..1480730 + 1545 WP_131069811.1 replication endonuclease -
FORC77_RS07200 1480852..1481682 + 831 WP_165480051.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1411980..1556552 144572
- inside Integron - - 1446959..1478434 31475


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T97044 WP_001247271.1 NZ_CP027030:c1476643-1476344 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T97044 NZ_CP027030:c1476643-1476344 [Vibrio vulnificus]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGCTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATTGAGATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT97044 WP_011080384.1 NZ_CP027030:c1476882-1476640 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT97044 NZ_CP027030:c1476882-1476640 [Vibrio vulnificus]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGGCGCTATGG
CTCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References