97043

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1439674..1440212 Replicon chromosome
Accession NZ_CP027030
Organism Vibrio vulnificus strain FORC_077

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag FORC77_RS06800 Protein ID WP_001247271.1
Coordinates 1439674..1439973 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag FORC77_RS06805 Protein ID WP_011080384.1
Coordinates 1439970..1440212 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC77_RS06765 1435228..1435449 + 222 Protein_1252 transposase -
FORC77_RS06770 1435533..1436384 + 852 WP_165480049.1 IS3 family transposase -
FORC77_RS06775 1436426..1437085 - 660 WP_131069791.1 DUF3800 domain-containing protein -
FORC77_RS06780 1437372..1437818 + 447 WP_077200563.1 GNAT family N-acetyltransferase -
FORC77_RS06785 1437954..1439066 + 1113 WP_131069792.1 hypothetical protein -
FORC77_RS06790 1439177..1439557 + 381 WP_029796920.1 hypothetical protein -
FORC77_RS06800 1439674..1439973 - 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC77_RS06805 1439970..1440212 - 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FORC77_RS06810 1440689..1441657 - 969 WP_011080312.1 IS30-like element ISVa6 family transposase -
FORC77_RS06815 1441739..1441894 + 156 WP_131070137.1 DUF3265 domain-containing protein -
FORC77_RS06820 1442033..1443241 + 1209 WP_131069793.1 site-specific integrase -
FORC77_RS06825 1443517..1443753 + 237 WP_131069794.1 helix-turn-helix domain-containing protein -
FORC77_RS06830 1443746..1443994 + 249 WP_118894212.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1411980..1556552 144572
- flank IS/Tn - - 1440689..1441465 776
- inside Integron - - 1412760..1440663 27903


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T97043 WP_001247271.1 NZ_CP027030:c1439973-1439674 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T97043 NZ_CP027030:c1439973-1439674 [Vibrio vulnificus]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATTGAAATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT97043 WP_011080384.1 NZ_CP027030:c1440212-1439970 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT97043 NZ_CP027030:c1440212-1439970 [Vibrio vulnificus]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGTCGCTATGG
CTCTGCAAGTGAAGTCATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References