Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4989958..4990618 Replicon chromosome
Accession NZ_CP027027
Organism Shigella dysenteriae strain E670/74

Toxin (Protein)


Gene name cptA Uniprot ID A0A398Q8H4
Locus tag C5S64_RS26995 Protein ID WP_000244782.1
Coordinates 4989958..4990371 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag C5S64_RS27000 Protein ID WP_000354046.1
Coordinates 4990352..4990618 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5S64_RS26975 4985921..4987654 - 1734 WP_000813168.1 single-stranded-DNA-specific exonuclease RecJ -
C5S64_RS26980 4987660..4988370 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C5S64_RS26985 4988395..4989291 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
C5S64_RS26990 4989403..4989924 + 522 WP_105242083.1 flavodoxin FldB -
C5S64_RS26995 4989958..4990371 - 414 WP_000244782.1 protein YgfX Toxin
C5S64_RS27000 4990352..4990618 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
C5S64_RS27005 4990861..4991841 + 981 WP_000886099.1 tRNA-modifying protein YgfZ -
C5S64_RS27010 4992037..4992696 - 660 WP_000250274.1 hemolysin III family protein -
C5S64_RS27015 4992860..4993171 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
C5S64_RS27020 4993216..4994649 + 1434 WP_005001089.1 6-phospho-beta-glucosidase BglA -
C5S64_RS27025 4994706..4995449 - 744 WP_000951944.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16305.25 Da        Isoelectric Point: 11.7064

>T97037 WP_000244782.1 NZ_CP027027:c4990371-4989958 [Shigella dysenteriae]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQRSR

Download         Length: 414 bp

>T97037 NZ_CP027027:c4990371-4989958 [Shigella dysenteriae]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACTCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATCAAGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT97037 WP_000354046.1 NZ_CP027027:c4990618-4990352 [Shigella dysenteriae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT97037 NZ_CP027027:c4990618-4990352 [Shigella dysenteriae]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A398Q8H4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References