Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3328386..3329024 Replicon chromosome
Accession NZ_CP027027
Organism Shigella dysenteriae strain E670/74

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag C5S64_RS18165 Protein ID WP_000813794.1
Coordinates 3328386..3328562 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C5S64_RS18170 Protein ID WP_001270286.1
Coordinates 3328608..3329024 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5S64_RS18145 3324008..3325219 - 1212 WP_075329958.1 BenE family transporter YdcO -
C5S64_RS18150 3325272..3325808 + 537 WP_000429147.1 DNA-binding transcriptional regulator SutR -
C5S64_RS18155 3325881..3327842 + 1962 WP_004998589.1 23S rRNA 5-hydroxycytidine C2501 synthase -
C5S64_RS18160 3327934..3328164 - 231 WP_000494244.1 YncJ family protein -
C5S64_RS18165 3328386..3328562 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
C5S64_RS18170 3328608..3329024 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
C5S64_RS18175 3329103..3330509 + 1407 WP_000760608.1 PLP-dependent aminotransferase family protein -
C5S64_RS18180 3330754..3331899 + 1146 WP_000047415.1 ABC transporter substrate-binding protein -
C5S64_RS18185 3331917..3332930 + 1014 WP_105241955.1 ABC transporter ATP-binding protein -
C5S64_RS28900 3332931..3333848 + 918 Protein_3287 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sodB / espR1 3252271..3520941 268670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T97033 WP_000813794.1 NZ_CP027027:3328386-3328562 [Shigella dysenteriae]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T97033 NZ_CP027027:3328386-3328562 [Shigella dysenteriae]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT97033 WP_001270286.1 NZ_CP027027:3328608-3329024 [Shigella dysenteriae]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT97033 NZ_CP027027:3328608-3329024 [Shigella dysenteriae]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGAGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATAGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References