Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1644672..1645222 Replicon chromosome
Accession NZ_CP027027
Organism Shigella dysenteriae strain E670/74

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag C5S64_RS08685 Protein ID WP_001160972.1
Coordinates 1644908..1645222 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag C5S64_RS08680 Protein ID WP_000125567.1
Coordinates 1644672..1644905 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5S64_RS08655 1639742..1640029 + 288 WP_000203741.1 ferredoxin-like protein FixX -
C5S64_RS08660 1640088..1641419 + 1332 WP_001183198.1 MFS transporter -
C5S64_RS08665 1641530..1642060 + 531 WP_000600743.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
C5S64_RS08670 1642053..1643915 + 1863 WP_000377139.1 glutathione-regulated potassium-efflux system protein KefC -
C5S64_RS08675 1644107..1644586 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
C5S64_RS08680 1644672..1644905 + 234 WP_000125567.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
C5S64_RS08685 1644908..1645222 + 315 WP_001160972.1 CcdB family protein Toxin
C5S64_RS08690 1645219..1646067 - 849 WP_000257196.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
C5S64_RS08695 1646074..1646451 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
C5S64_RS08700 1646454..1647275 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
C5S64_RS08705 1647272..1648261 - 990 WP_000241259.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
C5S64_RS08710 1648261..1649546 - 1286 Protein_1567 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11801.86 Da        Isoelectric Point: 9.0851

>T97017 WP_001160972.1 NZ_CP027027:1644908-1645222 [Shigella dysenteriae]
MQFTVYRSRSRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASTHRMLIKGALDFMLDGI

Download         Length: 315 bp

>T97017 NZ_CP027027:1644908-1645222 [Shigella dysenteriae]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCACGCACCGAATGTTGATTAAAGGAGCATTAGATTTTATGCTCGATGGGATTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8544.55 Da        Isoelectric Point: 5.8147

>AT97017 WP_000125567.1 NZ_CP027027:1644672-1644905 [Shigella dysenteriae]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSEEYRSF

Download         Length: 234 bp

>AT97017 NZ_CP027027:1644672-1644905 [Shigella dysenteriae]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGAGGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References