Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1469075..1469670 Replicon chromosome
Accession NZ_CP027027
Organism Shigella dysenteriae strain E670/74

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag C5S64_RS07830 Protein ID WP_000239579.1
Coordinates 1469320..1469670 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag C5S64_RS07825 Protein ID WP_001223208.1
Coordinates 1469075..1469326 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5S64_RS07815 1467083..1467424 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
C5S64_RS07820 1467464..1468810 - 1347 WP_004994989.1 IS4-like element IS4 family transposase -
C5S64_RS07825 1469075..1469326 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
C5S64_RS07830 1469320..1469670 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
C5S64_RS07835 1469750..1470280 - 531 WP_000055072.1 inorganic diphosphatase -
C5S64_RS07840 1470590..1471546 + 957 WP_000265938.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
C5S64_RS28745 1471687..1473189 + 1503 Protein_1403 sugar ABC transporter ATP-binding protein -
C5S64_RS07855 1473203..1474225 + 1023 WP_005002635.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1467464..1468792 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T97014 WP_000239579.1 NZ_CP027027:1469320-1469670 [Shigella dysenteriae]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T97014 NZ_CP027027:1469320-1469670 [Shigella dysenteriae]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT97014 WP_001223208.1 NZ_CP027027:1469075-1469326 [Shigella dysenteriae]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT97014 NZ_CP027027:1469075-1469326 [Shigella dysenteriae]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References