Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 4670617..4671182 Replicon chromosome
Accession NZ_CP027022
Organism Streptomyces sp. WAC00288

Toxin (Protein)


Gene name doc Uniprot ID A0A150VZH6
Locus tag C5L38_RS21285 Protein ID WP_030210020.1
Coordinates 4670811..4671182 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A150VZG3
Locus tag C5L38_RS21280 Protein ID WP_062755237.1
Coordinates 4670617..4670814 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5L38_RS21255 4666120..4666341 + 222 WP_062755230.1 helix-turn-helix domain-containing protein -
C5L38_RS21260 4666352..4667614 + 1263 WP_062757065.1 site-specific integrase -
C5L38_RS21265 4667818..4668672 + 855 WP_062755232.1 hypothetical protein -
C5L38_RS21275 4669076..4670584 + 1509 WP_062755235.1 MFS transporter -
C5L38_RS21280 4670617..4670814 + 198 WP_062755237.1 Arc family DNA-binding protein Antitoxin
C5L38_RS21285 4670811..4671182 + 372 WP_030210020.1 Fic family protein Toxin
C5L38_RS21290 4671301..4673097 + 1797 WP_062757066.1 DEAD/DEAH box helicase -
C5L38_RS21295 4673494..4674135 + 642 WP_030210027.1 helix-turn-helix domain-containing protein -
C5L38_RS21300 4674379..4675173 + 795 WP_062755239.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(11-81)

Antitoxin

Arc-like DNA binding domain

(5-39)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13647.47 Da        Isoelectric Point: 4.6142

>T97010 WP_030210020.1 NZ_CP027022:4670811-4671182 [Streptomyces sp. WAC00288]
VTYYLTLPEVLNLAQRLGADEVRDYGLLDSALARPQSSVFGQDAYPDVWQKAAALMESLARNHGLVDGNKRIAWYATWVF
LHMNGHPLDSAFDVDEAEAFVLDVCQGALDVPKIAAQLPRFAR

Download         Length: 372 bp

>T97010 NZ_CP027022:4670811-4671182 [Streptomyces sp. WAC00288]
GTGACGTACTACCTCACGCTCCCCGAGGTCCTGAACCTCGCGCAGCGGCTCGGCGCGGACGAGGTGCGGGACTACGGTCT
CCTCGACTCCGCCCTGGCACGTCCGCAGTCGAGCGTGTTCGGCCAGGACGCCTACCCGGACGTCTGGCAGAAGGCCGCGG
CGCTCATGGAATCGCTCGCCCGCAACCACGGACTCGTGGACGGGAACAAGCGCATCGCCTGGTACGCGACCTGGGTCTTC
CTCCACATGAACGGGCATCCGCTGGACTCGGCCTTCGACGTCGACGAGGCGGAGGCGTTCGTCCTGGACGTCTGCCAGGG
CGCCCTGGACGTCCCCAAGATCGCCGCGCAGCTGCCCCGGTTCGCGCGCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7436.28 Da        Isoelectric Point: 4.8377

>AT97010 WP_062755237.1 NZ_CP027022:4670617-4670814 [Streptomyces sp. WAC00288]
MAGLNVRFTEEELDALRERAEAEGRSMQSFAHDAVIRAINEHSRLFDEAAEHVLKVSEELNRRLA

Download         Length: 198 bp

>AT97010 NZ_CP027022:4670617-4670814 [Streptomyces sp. WAC00288]
ATGGCTGGTCTCAACGTCAGGTTCACCGAAGAAGAGCTGGACGCCCTGCGCGAGCGGGCCGAGGCGGAGGGGCGCAGCAT
GCAGTCCTTCGCGCACGACGCCGTGATCCGGGCCATAAACGAGCACTCCCGCCTCTTCGACGAGGCGGCCGAGCACGTGC
TGAAGGTCAGTGAGGAGCTGAACCGGAGGCTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A150VZH6

Antitoxin

Source ID Structure
AlphaFold DB A0A150VZG3

References