Detailed information of TA system TA097009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2750949..2751525
• Replicon: chromosome
• Accession: NZ_CP027017
• Organism: Treponema medium strain T19

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C5N99_RS12045
• Protein ID: WP_206182047.1
• Coordinates: 2750949..2751137 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C5N99_RS12050
• Protein ID: WP_206182048.1
• Coordinates: 2751142..2751525 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5N99_RS12025	2746011..2746589	+	579	WP_206182046.1	hypothetical protein	-
C5N99_RS12030	2746773..2747858	+	1086	WP_206183000.1	glycosyltransferase	-
C5N99_RS12035	2747885..2749537	-	1653	WP_016524183.1	nucleoside kinase	-
C5N99_RS12045	2750949..2751137	+	189	WP_206182047.1	type II toxin-antitoxin system HicA family toxin	Toxin
C5N99_RS12050	2751142..2751525	+	384	WP_206182048.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C5N99_RS12055	2751668..2753188	-	1521	WP_206182049.1	MiaB/RimO family radical SAM methylthiotransferase	-
C5N99_RS12060	2753181..2754299	-	1119	WP_206182050.1	helix-turn-helix domain-containing protein	-
C5N99_RS12065	2754337..2755023	-	687	WP_016524188.1	outer membrane lipoprotein carrier protein LolA	-
C5N99_RS12070	2755321..2755857	-	537	WP_206182051.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-102)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7218.43 Da
• Isoelectric Point: 10.4338

>T97009 WP_206182047.1 NZ_CP027017:2750949-2751137 [Treponema medium]
MNFKEMEKMIKQDGWVKRDIVGSHHHYEHSVKKGKVTIPFHGNKELSKFVVNSILKQAGLKE

Nucleotide

• Length: 189 bp

>T97009 NZ_CP027017:2750949-2751137 [Treponema medium]
ATGAACTTTAAAGAAATGGAGAAGATGATAAAACAAGACGGATGGGTAAAACGTGATATAGTTGGGTCACATCATCACTA
TGAGCATTCGGTTAAAAAAGGGAAGGTTACTATTCCATTTCACGGTAATAAGGAGCTTTCAAAGTTTGTAGTAAATAGTA
TTCTTAAACAAGCAGGATTAAAGGAGTAA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14301.40 Da
• Isoelectric Point: 4.3514

>AT97009 WP_206182048.1 NZ_CP027017:2751142-2751525 [Treponema medium]
MYIYPAIFYKDENGYSVVFYDIELATMGDTLEEALIMAEEALTGRISLLLKDGETLPNPTSIEDIEKPKDAEFITLIKTD
RKYLAQEKSVRKNLTIPAWLAEAAENAGLNFSQELQCALKTRLHIGV

Nucleotide

• Length: 384 bp

>AT97009 NZ_CP027017:2751142-2751525 [Treponema medium]
ATGTATATTTATCCGGCAATTTTTTATAAAGATGAAAACGGTTATTCGGTTGTATTTTATGATATAGAACTTGCAACGAT
GGGAGACACATTGGAAGAAGCGTTGATAATGGCAGAGGAAGCATTGACAGGACGTATCTCTTTACTTTTAAAGGATGGAG
AGACACTGCCCAATCCGACTTCTATAGAAGATATAGAAAAACCGAAAGATGCGGAATTTATTACACTGATAAAAACCGAC
CGTAAATACCTGGCACAGGAAAAAAGTGTTCGTAAAAACTTAACAATTCCTGCATGGCTTGCTGAAGCTGCCGAAAATGC
AGGGTTAAATTTTTCGCAAGAGTTGCAATGTGCTCTAAAAACGCGCTTGCATATTGGAGTATAA