Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2075056..2075621 Replicon chromosome
Accession NZ_CP027017
Organism Treponema medium strain T19

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag C5N99_RS09060 Protein ID WP_206181650.1
Coordinates 2075056..2075394 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A898DFU9
Locus tag C5N99_RS09065 Protein ID WP_016523603.1
Coordinates 2075388..2075621 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5N99_RS09045 2070727..2071293 + 567 WP_206181647.1 redoxin domain-containing protein -
C5N99_RS09050 2071505..2074300 - 2796 WP_206181648.1 hypothetical protein -
C5N99_RS09055 2074494..2074718 - 225 WP_206181649.1 hypothetical protein -
C5N99_RS09060 2075056..2075394 - 339 WP_206181650.1 endoribonuclease MazF Toxin
C5N99_RS09065 2075388..2075621 - 234 WP_016523603.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C5N99_RS09070 2075923..2077227 + 1305 WP_206181651.1 OmpA family protein -
C5N99_RS09075 2077255..2077998 - 744 WP_206181652.1 ThiF family adenylyltransferase -
C5N99_RS09080 2078029..2079088 - 1060 Protein_1759 phospho-N-acetylmuramoyl-pentapeptide- transferase -
C5N99_RS09085 2079543..2080046 - 504 WP_206181653.1 crossover junction endodeoxyribonuclease RuvC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12737.76 Da        Isoelectric Point: 6.0672

>T97008 WP_206181650.1 NZ_CP027017:c2075394-2075056 [Treponema medium]
MVIIGFIPEKGDLVWLEFNPQAGHEQQGHRPAMCVSQKLYNQKTGLALFCPITSHIKGYPFEVVLNDHSIKGCILSDQIK
NLDYVQRKCSFIEKASEDEINSVIDNIKLMME

Download         Length: 339 bp

>T97008 NZ_CP027017:c2075394-2075056 [Treponema medium]
ATGGTAATTATCGGTTTTATTCCTGAAAAAGGAGATTTAGTTTGGTTAGAATTTAATCCACAAGCAGGACATGAACAACA
GGGACATAGACCTGCAATGTGTGTTTCTCAAAAATTATATAACCAAAAAACAGGATTGGCGTTATTTTGCCCAATTACAA
GTCACATAAAAGGCTATCCATTTGAAGTCGTTTTAAATGACCATTCAATAAAAGGTTGTATTTTGAGTGATCAAATAAAA
AACTTGGATTATGTTCAAAGAAAATGCAGTTTTATAGAAAAAGCTTCAGAAGATGAAATAAATTCTGTAATAGATAATAT
AAAACTGATGATGGAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8706.09 Da        Isoelectric Point: 7.0128

>AT97008 WP_016523603.1 NZ_CP027017:c2075621-2075388 [Treponema medium]
MQAVVQKWGNSLGLRIPSLWAKDNNVKNGSKVEVIAEKGKMLILPQKKSLEDIMNLVTDENIHSEIKTFEAVGKEEW

Download         Length: 234 bp

>AT97008 NZ_CP027017:c2075621-2075388 [Treponema medium]
ATGCAGGCAGTAGTTCAGAAATGGGGAAATAGTCTCGGGCTTAGAATTCCGTCACTTTGGGCAAAAGATAACAATGTTAA
AAATGGAAGCAAAGTAGAAGTAATTGCAGAAAAAGGGAAAATGCTCATTCTTCCTCAAAAAAAATCACTTGAAGATATTA
TGAATCTTGTTACGGATGAAAATATCCATTCAGAAATAAAAACTTTTGAAGCAGTAGGAAAAGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References