Detailed information of TA system TA097007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 785410..786047
• Replicon: chromosome
• Accession: NZ_CP027017
• Organism: Treponema medium strain T19

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C5N99_RS03500
• Protein ID: WP_016522664.1
• Coordinates: 785410..785817 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A898DEW2
• Locus tag: C5N99_RS03505
• Protein ID: WP_016522665.1
• Coordinates: 785817..786047 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5N99_RS03490	781521..781976	-	456	Protein_676	PD-(D/E)XK nuclease family protein	-
C5N99_RS03495	782221..785133	-	2913	Protein_677	UvrD-helicase domain-containing protein	-
C5N99_RS03500	785410..785817	-	408	WP_016522664.1	type II toxin-antitoxin system VapC family toxin	Toxin
C5N99_RS03505	785817..786047	-	231	WP_016522665.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
C5N99_RS03510	786233..787294	-	1062	WP_016522666.1	hypothetical protein	-
C5N99_RS03515	787299..787550	-	252	WP_206181077.1	DUF1232 domain-containing protein	-
C5N99_RS03520	789423..790058	+	636	Protein_682	ISAs1 family transposase	-
C5N99_RS03525	790150..790653	+	504	Protein_683	ISAs1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15682.04 Da
• Isoelectric Point: 6.9290

>T97007 WP_016522664.1 NZ_CP027017:c785817-785410 [Treponema medium]
MYLLDTNICIFLIKNKNPYLKKKIFNCKKEELFISSITIAELEYGVSKSQFREKNRHALLNFCSDFTNIIDFTTEDTETY
GMIRAYLENKGIPIGPFDTQIAAQSLARNLTVVTNNIREFSRIPGLKVEDWTKEE

Nucleotide

• Length: 408 bp

>T97007 NZ_CP027017:c785817-785410 [Treponema medium]
ATGTATTTGCTAGATACAAATATCTGTATTTTTCTTATAAAGAATAAAAATCCATATTTAAAGAAAAAAATATTTAACTG
TAAAAAAGAAGAATTATTTATTTCTTCCATTACAATTGCTGAGCTGGAGTATGGTGTTTCAAAAAGTCAATTTAGAGAAA
AGAATCGTCATGCTCTTTTGAATTTTTGTTCCGATTTTACTAACATAATAGATTTTACGACCGAAGATACAGAAACGTAC
GGAATGATTAGAGCATATCTTGAAAATAAAGGAATTCCGATTGGACCTTTTGATACGCAGATTGCCGCTCAAAGTTTAGC
AAGAAATCTTACTGTGGTTACAAATAATATAAGAGAATTTTCTAGAATTCCAGGACTAAAAGTCGAAGACTGGACAAAAG
AAGAATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8761.91 Da
• Isoelectric Point: 4.7660

>AT97007 WP_016522665.1 NZ_CP027017:c786047-785817 [Treponema medium]
MVYAKVFTSGNSQAVRIPKEFHIDFSELCIKKIGSSIILTPKESNWENLERSLSEFSDDFMTEGRSQPAMQEREVF

Nucleotide

• Length: 231 bp

>AT97007 NZ_CP027017:c786047-785817 [Treponema medium]
ATGGTTTATGCAAAAGTATTCACAAGTGGAAATAGTCAGGCAGTAAGGATACCGAAAGAATTTCATATTGATTTTTCTGA
ATTATGCATCAAGAAAATCGGCTCATCAATAATCTTAACACCAAAAGAAAGCAATTGGGAAAATCTTGAAAGAAGTCTTT
CTGAGTTTTCTGATGATTTCATGACAGAAGGTAGAAGTCAACCGGCAATGCAAGAACGGGAAGTTTTTTAA