Detailed information of TA system TA097006

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3119..3717
• Replicon: chromosome
• Accession: NZ_CP027017
• Organism: Treponema medium strain T19

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C5N99_RS00020
• Protein ID: WP_016522085.1
• Coordinates: 3119..3487 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A898DCS2
• Locus tag: C5N99_RS00025
• Protein ID: WP_016522086.1
• Coordinates: 3487..3717 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5N99_RS00005	108..1463	+	1356	WP_206182127.1	restriction endonuclease subunit S	-
C5N99_RS00010	1434..2192	-	759	WP_206182125.1	restriction endonuclease subunit S	-
C5N99_RS00015	2091..2900	+	810	WP_206182126.1	tyrosine-type recombinase/integrase	-
C5N99_RS00020	3119..3487	-	369	WP_016522085.1	PIN domain-containing protein	Toxin
C5N99_RS00025	3487..3717	-	231	WP_016522086.1	hypothetical protein	Antitoxin
C5N99_RS00030	4101..4733	-	633	WP_156831484.1	restriction endonuclease subunit S	-
C5N99_RS00035	5050..5259	+	210	WP_040858883.1	hypothetical protein	-
C5N99_RS00040	5681..6703	+	1023	WP_206181022.1	slipin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 14109.38 Da
• Isoelectric Point: 7.8308

>T97006 WP_016522085.1 NZ_CP027017:c3487-3119 [Treponema medium]
VYLLDTNICIYIINNRPERVREKLKSIDHRIIYLSTISFGELQYGAYKSSKPEESKHALLDFVKPFTFVDFTTEDAEAFG
AIRAYLERKGNVIGAYDMQIAAQAMTRNFIYTKLLYILPIIC

Nucleotide

• Length: 369 bp

>T97006 NZ_CP027017:c3487-3119 [Treponema medium]
GTGTATTTACTTGATACAAATATCTGTATATATATTATAAATAATCGACCTGAACGAGTACGAGAAAAACTAAAAAGCAT
TGATCATAGAATCATATATCTTTCAACAATTTCATTCGGCGAATTGCAATATGGGGCATACAAGAGCAGTAAACCGGAAG
AGAGCAAGCATGCATTACTGGATTTTGTAAAACCTTTTACATTTGTTGATTTCACGACAGAAGATGCGGAAGCATTCGGT
GCAATTCGGGCATATTTAGAAAGAAAAGGCAATGTAATTGGGGCGTATGATATGCAAATTGCTGCACAGGCTATGACAAG
AAACTTCATATATACAAAGTTGCTTTATATACTGCCGATAATATGTTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8813.97 Da
• Isoelectric Point: 7.9812

>AT97006 WP_016522086.1 NZ_CP027017:c3717-3487 [Treponema medium]
MTYAKVFISGNSQAIRLPKSFQVSDNQLCIKKIGSSIVLFREDNPWDSFDRSLNKFPDDFFIEGRKQPETQQREGI

Nucleotide

• Length: 231 bp

>AT97006 NZ_CP027017:c3717-3487 [Treponema medium]
ATGACATATGCAAAAGTCTTTATAAGCGGTAATAGCCAAGCGATACGGCTACCAAAAAGTTTTCAGGTATCTGACAATCA
ATTATGTATTAAAAAAATCGGTTCATCAATTGTGTTATTCCGCGAAGATAATCCATGGGATAGTTTTGATAGAAGTTTAA
ATAAATTTCCTGATGATTTTTTTATAGAGGGACGGAAACAACCGGAAACACAACAACGGGAAGGTATTTAG