Detailed information of TA system TA097005

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PIN-RelB
• Location: 1389589..1390496
• Replicon: chromosome
• Accession: NZ_CP026999
• Organism: Bifidobacterium longum strain 51A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Blongum51A_RS06300
• Protein ID: WP_136656108.1
• Coordinates: 1389589..1390134 (-)
• Length: 182 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V6XX41
• Locus tag: Blongum51A_RS06305
• Protein ID: WP_008783109.1
• Coordinates: 1390134..1390496 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Blongum51A_RS06280	1384702..1385934	+	1233	WP_007056207.1	sensor histidine kinase	-
Blongum51A_RS06285	1385969..1386694	+	726	WP_007056206.1	response regulator transcription factor	-
Blongum51A_RS06290	1386734..1387375	+	642	WP_165500638.1	GNAT family N-acetyltransferase	-
Blongum51A_RS06295	1387464..1389569	+	2106	WP_131203651.1	DUF262 domain-containing protein	-
Blongum51A_RS06300	1389589..1390134	-	546	WP_136656108.1	PIN domain-containing protein	Toxin
Blongum51A_RS06305	1390134..1390496	-	363	WP_008783109.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
Blongum51A_RS06310	1390642..1393341	-	2700	WP_008783110.1	aconitate hydratase AcnA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1276930..1456426	179496

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-141)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-53)

Sequences

Toxin

Protein

• Length: 182 a.a.
• Molecular weight: 20164.91 Da
• Isoelectric Point: 4.7886

>T97005 WP_136656108.1 NZ_CP026999:c1390134-1389589 [Bifidobacterium longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNITLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALRGGTGINERLASLTEGSHQ

Nucleotide

• Length: 546 bp

>T97005 NZ_CP026999:c1390134-1389589 [Bifidobacterium longum]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTCGATACCAACGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACATTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATCGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCACTGCGTGGCGGCACTGGAATAAATGAGCGGTTGGCTTCCCTCACGGAGGGGAGCCACCAATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13974.03 Da
• Isoelectric Point: 5.0733

>AT97005 WP_008783109.1 NZ_CP026999:c1390496-1390134 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Nucleotide

• Length: 363 bp

>AT97005 NZ_CP026999:c1390496-1390134 [Bifidobacterium longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTACACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATGCGTATTACAACATGAAGAGGGCCGATTGA

Structures

Antitoxin

• AlphaFold DB: V6XX41