Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 1660069..1660711 | Replicon | chromosome |
| Accession | NC_000911 | ||
| Organism | Synechocystis sp. PCC 6803 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | slr1327 | Protein ID | WP_010872706.1 |
| Coordinates | 1660277..1660711 (+) | Length | 145 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | ssr2201 | Protein ID | WP_010872705.1 |
| Coordinates | 1660069..1660287 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SGL_RS09655 (sll1236) | 1655289..1655672 | - | 384 | WP_010872702.1 | heterocyst frequency control protein PatD | - |
| SGL_RS09660 (slr1325) | 1656043..1658325 | + | 2283 | WP_010872703.1 | RelA/SpoT family protein | - |
| SGL_RS09665 (sll1234) | 1658511..1659788 | - | 1278 | WP_010872704.1 | adenosylhomocysteinase | - |
| SGL_RS09670 (ssr2201) | 1660069..1660287 | + | 219 | WP_010872705.1 | hypothetical protein | Antitoxin |
| SGL_RS09675 (slr1327) | 1660277..1660711 | + | 435 | WP_010872706.1 | putative toxin-antitoxin system toxin component, PIN family | Toxin |
| SGL_RS09680 (sll1233) | 1660739..1661623 | - | 885 | WP_010872707.1 | transglutaminase family protein | - |
| SGL_RS09685 (sll1232) | 1661722..1662285 | - | 564 | WP_010872708.1 | Uma2 family endonuclease | - |
| SGL_RS09690 (sll1231) | 1662306..1663505 | - | 1200 | WP_010872709.1 | glycosyltransferase family 4 protein | - |
| SGL_RS09695 (sll1229) | 1663554..1664690 | - | 1137 | WP_010872710.1 | hybrid sensor histidine kinase/response regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 145 a.a. Molecular weight: 16459.94 Da Isoelectric Point: 4.4099
>T970 WP_010872706.1 NC_000911:1660277-1660711 [Synechocystis sp. PCC 6803]
MNNEVIRVVIDTNIWISFLIGKTLQGLNQAIIDNQVVILFSDTLFTELMEVLHHPKFKKYFSGTAIQNLIALLNEKVELV
EVNLHFDSYRDKKDNFLLDLAVSGNANYLVTGDSDLLTLNPFDNVEIISYQHFQAIILAMMDNQ
MNNEVIRVVIDTNIWISFLIGKTLQGLNQAIIDNQVVILFSDTLFTELMEVLHHPKFKKYFSGTAIQNLIALLNEKVELV
EVNLHFDSYRDKKDNFLLDLAVSGNANYLVTGDSDLLTLNPFDNVEIISYQHFQAIILAMMDNQ
Download Length: 435 bp
>T970 NC_000911:1660277-1660711 [Synechocystis sp. PCC 6803]
ATGAACAATGAAGTTATCCGGGTTGTAATTGATACGAATATCTGGATCAGTTTTCTAATTGGAAAAACTCTTCAAGGTTT
AAATCAAGCCATCATTGATAACCAAGTGGTCATTTTATTCAGTGACACTTTGTTTACTGAGCTGATGGAAGTATTACACC
ATCCTAAATTCAAAAAGTACTTTTCCGGAACAGCCATCCAAAATTTAATCGCACTGTTAAACGAAAAAGTTGAATTGGTT
GAAGTGAATCTTCATTTTGACAGTTATCGAGACAAAAAAGATAATTTCTTGCTGGATTTGGCAGTCTCAGGCAATGCAAA
TTATTTGGTGACGGGAGATAGTGACCTATTGACATTAAACCCATTTGACAATGTAGAAATTATCTCCTATCAACATTTTC
AAGCTATTATTTTAGCCATGATGGATAATCAGTAA
ATGAACAATGAAGTTATCCGGGTTGTAATTGATACGAATATCTGGATCAGTTTTCTAATTGGAAAAACTCTTCAAGGTTT
AAATCAAGCCATCATTGATAACCAAGTGGTCATTTTATTCAGTGACACTTTGTTTACTGAGCTGATGGAAGTATTACACC
ATCCTAAATTCAAAAAGTACTTTTCCGGAACAGCCATCCAAAATTTAATCGCACTGTTAAACGAAAAAGTTGAATTGGTT
GAAGTGAATCTTCATTTTGACAGTTATCGAGACAAAAAAGATAATTTCTTGCTGGATTTGGCAGTCTCAGGCAATGCAAA
TTATTTGGTGACGGGAGATAGTGACCTATTGACATTAAACCCATTTGACAATGTAGAAATTATCTCCTATCAACATTTTC
AAGCTATTATTTTAGCCATGATGGATAATCAGTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8400.43 Da Isoelectric Point: 4.2583
>AT970 WP_010872705.1 NC_000911:1660069-1660287 [Synechocystis sp. PCC 6803]
MHSLSSLEFPELKSVIAQCNLEEKLELLELLEKDTFGTRFNKFLNSVKTDELTLEDITQEVESVRQANYHEQ
MHSLSSLEFPELKSVIAQCNLEEKLELLELLEKDTFGTRFNKFLNSVKTDELTLEDITQEVESVRQANYHEQ
Download Length: 219 bp
>AT970 NC_000911:1660069-1660287 [Synechocystis sp. PCC 6803]
ATGCACTCATTGTCATCACTGGAATTTCCTGAGCTTAAAAGTGTTATTGCCCAATGTAATCTTGAAGAAAAACTTGAATT
ATTAGAACTTTTGGAAAAGGATACTTTTGGCACCAGATTTAACAAATTTTTAAATTCTGTCAAAACTGACGAATTAACCT
TAGAAGACATTACACAAGAAGTTGAATCGGTCCGGCAAGCTAATTATCATGAACAATGA
ATGCACTCATTGTCATCACTGGAATTTCCTGAGCTTAAAAGTGTTATTGCCCAATGTAATCTTGAAGAAAAACTTGAATT
ATTAGAACTTTTGGAAAAGGATACTTTTGGCACCAGATTTAACAAATTTTTAAATTCTGTCAAAACTGACGAATTAACCT
TAGAAGACATTACACAAGAAGTTGAATCGGTCCGGCAAGCTAATTATCATGAACAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Qian Fei et al. (2018) A Toxin-Antitoxin System VapBC15 from Synechocystis sp. PCC 6803 Shows Distinct Regulatory Features. Genes 9(4):173. [PubMed:29561797]