Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4003640..4004300 Replicon chromosome
Accession NZ_CP026982
Organism Pectobacterium parmentieri strain IFB5486

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B3EZX7
Locus tag C5E22_RS18645 Protein ID WP_012822581.1
Coordinates 4003640..4004053 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3I0G9
Locus tag C5E22_RS18650 Protein ID WP_012822580.1
Coordinates 4004034..4004300 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5E22_RS18615 3998681..3999499 - 819 WP_033071942.1 MetQ/NlpA family ABC transporter substrate-binding protein -
C5E22_RS18620 3999517..4000185 - 669 WP_012822586.1 ABC transporter permease -
C5E22_RS18625 4000178..4001194 - 1017 WP_012822585.1 methionine ABC transporter ATP-binding protein -
C5E22_RS18630 4001522..4002040 + 519 WP_033070904.1 flavodoxin FldB -
C5E22_RS18635 4002069..4002392 + 324 WP_012822583.1 hypothetical protein -
C5E22_RS18640 4002479..4003414 - 936 WP_012822582.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
C5E22_RS18645 4003640..4004053 - 414 WP_012822581.1 protein YgfX Toxin
C5E22_RS18650 4004034..4004300 - 267 WP_012822580.1 FAD assembly factor SdhE Antitoxin
C5E22_RS18655 4004528..4005529 + 1002 WP_012822579.1 tRNA-modifying protein YgfZ -
C5E22_RS18660 4005584..4006231 - 648 WP_012822578.1 hemolysin III family protein -
C5E22_RS18665 4006640..4007248 + 609 WP_014698756.1 HD domain-containing protein -
C5E22_RS18670 4007302..4008306 + 1005 WP_012822576.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16259.20 Da        Isoelectric Point: 10.7923

>T96964 WP_012822581.1 NZ_CP026982:c4004053-4003640 [Pectobacterium parmentieri]
VAQWQCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGCITLLSETTLNWRQQ
EWRIVKRPWLLKNGVLLALQSANGKDKQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Download         Length: 414 bp

>T96964 NZ_CP026982:c4004053-4003640 [Pectobacterium parmentieri]
GTGGCCCAGTGGCAATGTGACCTTCGCGTTTCCTGGCGCATGCAACTGCTGTCATTGGTTGTGCATGGTCTATTAGTGTT
GCTCATTCTGCTGGCACCGTGGCCGGACGGCTATGCGTGGCTGTGGCTGTGTTTGGTCACAATGGTGATGTTTGGTTTCA
TCCGTAGCCAAAGGAATATCAAATCGCGGCAAGGGTGCATCACGCTGCTTAGCGAAACGACCTTGAACTGGCGGCAGCAG
GAGTGGCGGATTGTCAAACGACCGTGGTTGCTGAAAAATGGTGTGTTATTGGCATTGCAATCGGCTAATGGGAAAGACAA
GCAACAACTGTGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGTCATCTGCGCCAGCTTCTTTTGCAGCAAAAAC
ACTGGGCGAGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.99 Da        Isoelectric Point: 5.1392

>AT96964 WP_012822580.1 NZ_CP026982:c4004300-4004034 [Pectobacterium parmentieri]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDIDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT96964 NZ_CP026982:c4004300-4004034 [Pectobacterium parmentieri]
ATGGAAATCGATAACAAATCACGTATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTGGATATCGCCATCATGCCGTT
TTTTGAGCATGACTATGACACATTAAACGATATAGATAAGCGCACGTTTGTACGCCTGCTACAAAGCGACGATCCCGATT
TATTCAACTGGCTAATGAACCACGGTGAGCCAGAAGACGGAGAGCTAAAACGCATGATTTCCCTTATCCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3EZX7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3I0G9

References