Detailed information of TA system TA096947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1843418..1843971
• Replicon: chromosome
• Accession: NZ_CP026980
• Organism: Pectobacterium parmentieri strain IFB5441

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: C5E20_RS08930
• Protein ID: WP_121268804.1
• Coordinates: 1843657..1843971 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A0H3I2T3
• Locus tag: C5E20_RS08925
• Protein ID: WP_014699357.1
• Coordinates: 1843418..1843654 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5E20_RS24050	1841478..1841681	-	204	WP_162939924.1	hypothetical protein	-
C5E20_RS08920	1842155..1843099	+	945	WP_121268802.1	DUF1738 domain-containing protein	-
C5E20_RS08925	1843418..1843654	+	237	WP_014699357.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
C5E20_RS08930	1843657..1843971	+	315	WP_121268804.1	CcdB family protein	Toxin
C5E20_RS08935	1844005..1844259	-	255	WP_121268806.1	mobilization protein mobC	-
C5E20_RS08940	1844352..1845398	+	1047	WP_121268808.1	DUF3800 domain-containing protein	-
C5E20_RS08945	1845756..1846052	-	297	WP_121268810.1	hypothetical protein	-
C5E20_RS08950	1846320..1847306	-	987	WP_121268812.1	hypothetical protein	-
C5E20_RS24055	1847566..1847724	+	159	WP_162939925.1	hypothetical protein	-
C5E20_RS08955	1848189..1848806	+	618	WP_121268814.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1801607..1874669	73062

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11522.44 Da
• Isoelectric Point: 6.9742

>T96947 WP_121268804.1 NZ_CP026980:1843657-1843971 [Pectobacterium parmentieri]
MQFTVYGNTGKSVVYPLLLDVTSDIIGELNRRIVIPLLPIEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRSQVKAAIDFLIDGF

Nucleotide

• Length: 315 bp

>T96947 NZ_CP026980:1843657-1843971 [Pectobacterium parmentieri]
ATGCAATTCACTGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GGAATTGAATCGTCGGATAGTGATCCCATTGCTCCCTATTGAAAAGTATCCGGCAGGTCGCCGACCGGATCGTCTTGTAC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACCCACGAACTGGCCAGTATCCCTGTCCAGGCTCTGGGG
GCGGTGTTTTGTGATGCGTCGCAGTACCGTTCTCAGGTAAAGGCTGCAATAGACTTCCTCATCGATGGGTTCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9004.06 Da
• Isoelectric Point: 6.4610

>AT96947 WP_014699357.1 NZ_CP026980:1843418-1843654 [Pectobacterium parmentieri]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRYHEAKKWQEENREALAALNRFHDEQGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT96947 NZ_CP026980:1843418-1843654 [Pectobacterium parmentieri]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACAGTAGAGCGTGCCTTACTGGTAAGAGCGCGTGAGGCGGG
TATTAATCTGAGTGCTACCCTGACAACCGCCCTGGATGCAGAGCTTCGCTATCATGAAGCGAAAAAATGGCAAGAAGAAA
ACAGGGAGGCTCTCGCAGCACTAAATCGTTTTCATGATGAACAGGGTTGTTTCAGCGATGAATACAGGACGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3I2T3