Detailed information of TA system TA096941

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3412948..3413575
• Replicon: chromosome
• Accession: NZ_CP026979
• Organism: Pectobacterium parmentieri strain IFB5432

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: C6DB72
• Locus tag: C5E19_RS16125
• Protein ID: WP_005976087.1
• Coordinates: 3413372..3413575 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: C5E19_RS16120
• Protein ID: WP_121247122.1
• Coordinates: 3412948..3413316 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5E19_RS16105	3408419..3411547	+	3129	WP_015730969.1	multidrug efflux RND transporter permease subunit	-
C5E19_RS16110	3411780..3412028	+	249	WP_015730970.1	type B 50S ribosomal protein L31	-
C5E19_RS16115	3412046..3412189	+	144	WP_005976091.1	type B 50S ribosomal protein L36	-
C5E19_RS16120	3412948..3413316	+	369	WP_121247122.1	Hha toxicity modulator TomB	Antitoxin
C5E19_RS16125	3413372..3413575	+	204	WP_005976087.1	hemolysin expression modulator Hha	Toxin
C5E19_RS16135	3414303..3414623	+	321	WP_005976085.1	MGMT family protein	-
C5E19_RS16140	3414643..3415227	-	585	WP_015730971.1	YbaY family lipoprotein	-
C5E19_RS16145	3415438..3416301	+	864	WP_121265854.1	acyl-CoA thioesterase II	-
C5E19_RS16150	3416419..3417705	-	1287	WP_014700821.1	ammonium transporter AmtB	-
C5E19_RS16155	3417745..3418083	-	339	WP_002208627.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8145.52 Da
• Isoelectric Point: 8.9008

>T96941 WP_005976087.1 NZ_CP026979:3413372-3413575 [Pectobacterium parmentieri]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Nucleotide

• Length: 204 bp

>T96941 NZ_CP026979:3413372-3413575 [Pectobacterium parmentieri]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACGATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCCAATGATGAACTGGAGATGTTCTTTTCTGCAGCCGATCATCGCCTGGCAGAGTTGACGATGAACAAAC
TCTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14004.71 Da
• Isoelectric Point: 4.3689

>AT96941 WP_121247122.1 NZ_CP026979:3412948-3413316 [Pectobacterium parmentieri]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELQRWQKSKAKLFGMFSGENVCTPAKT

Nucleotide

• Length: 369 bp

>AT96941 NZ_CP026979:3412948-3413316 [Pectobacterium parmentieri]
ATGGATGAGTACACACCAAAGCATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGATGAGAGCATAGC
AACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACTTCTGCGATCAATCTCCAATTAAATGAGCTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTCTCAGAGCAGGTTGAAAAATATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGTATTAATGACGCTGAACTACAACGCTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Structures

Toxin

• AlphaFold DB: A0A1D7Z3F0