Detailed information of TA system TA096940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 3379093..3379725
• Replicon: chromosome
• Accession: NZ_CP026979
• Organism: Pectobacterium parmentieri strain IFB5432

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C5E19_RS15920
• Protein ID: WP_072014142.1
• Coordinates: 3379549..3379725 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C5E19_RS15915
• Protein ID: WP_121265806.1
• Coordinates: 3379093..3379500 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5E19_RS15880	3374258..3375865	-	1608	WP_121265792.1	terminase large subunit	-
C5E19_RS15885	3376085..3376558	-	474	WP_121265794.1	DUF2280 domain-containing protein	-
C5E19_RS15890	3376589..3377227	-	639	WP_121265796.1	hypothetical protein	-
C5E19_RS15895	3377344..3377589	-	246	WP_121265798.1	hypothetical protein	-
C5E19_RS15900	3377682..3378227	-	546	WP_205577247.1	hypothetical protein	-
C5E19_RS15905	3378230..3378670	-	441	WP_121265802.1	lysozyme	-
C5E19_RS15910	3378654..3378995	-	342	WP_121265804.1	phage holin, lambda family	-
C5E19_RS15915	3379093..3379500	-	408	WP_121265806.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C5E19_RS15920	3379549..3379725	-	177	WP_072014142.1	type II toxin-antitoxin system HicA family toxin	Toxin
C5E19_RS15925	3379786..3380511	-	726	WP_121265808.1	protein mom	-
C5E19_RS15930	3380745..3381149	-	405	WP_121265810.1	antitermination protein	-
C5E19_RS15935	3381149..3382006	-	858	WP_121265812.1	helix-turn-helix domain-containing protein	-
C5E19_RS15940	3381996..3383387	-	1392	WP_121265814.1	replicative DNA helicase	-
C5E19_RS15945	3383384..3384253	-	870	WP_121265816.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3352045..3392772	40727

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-63)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6725.79 Da
• Isoelectric Point: 11.3427

>T96940 WP_072014142.1 NZ_CP026979:c3379725-3379549 [Pectobacterium parmentieri]
VKQSEFRRWLESQGVEVSNGTNHLKLRYNGNRSVMPRHPSAEIKEPLRKAILKQLGLK

Nucleotide

• Length: 177 bp

>T96940 NZ_CP026979:c3379725-3379549 [Pectobacterium parmentieri]
GTGAAGCAAAGCGAGTTCAGGCGGTGGCTTGAATCTCAGGGGGTTGAGGTTTCAAACGGTACAAATCATTTGAAGCTGAG
ATACAACGGGAATCGAAGTGTAATGCCGAGACACCCGAGCGCTGAGATAAAAGAACCATTGCGAAAGGCCATACTTAAAC
AGCTTGGCCTGAAATAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14724.81 Da
• Isoelectric Point: 4.3759

>AT96940 WP_121265806.1 NZ_CP026979:c3379500-3379093 [Pectobacterium parmentieri]
MRYPVNLDPDSGGYIVSFPDIPEALTQGDTREDALKEALDALVTAFEFYFEDNQRIPAPGNITGDCVEVPASIAAKVLML
NAFVDSGLTQVELASRMGVKKQEVTRLFDLHHSTKIDTIQKAISAMGLRLELVAA

Nucleotide

• Length: 408 bp

>AT96940 NZ_CP026979:c3379500-3379093 [Pectobacterium parmentieri]
ATGCGATATCCAGTAAATTTAGACCCGGACTCAGGCGGCTATATTGTGTCGTTCCCTGATATACCGGAAGCCCTGACGCA
AGGGGATACGCGGGAAGATGCGTTAAAAGAGGCGCTGGATGCGCTGGTGACGGCCTTCGAGTTTTATTTCGAAGATAACC
AGCGTATTCCGGCACCCGGTAACATAACGGGTGATTGCGTAGAGGTTCCGGCCAGCATTGCCGCTAAGGTTTTAATGCTG
AATGCGTTTGTTGATTCCGGCTTAACTCAGGTTGAGCTGGCTTCACGCATGGGTGTAAAAAAACAGGAGGTAACCCGACT
GTTTGACCTGCATCACTCAACGAAAATAGACACAATTCAAAAGGCGATCTCTGCAATGGGATTGCGCCTGGAGCTGGTGG
CCGCTTAA