Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3476921..3477548 Replicon chromosome
Accession NZ_CP026977
Organism Pectobacterium parmentieri strain IFB5408

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag C5E17_RS16450 Protein ID WP_005976087.1
Coordinates 3477345..3477548 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag C5E17_RS16445 Protein ID WP_005976089.1
Coordinates 3476921..3477289 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5E17_RS16430 3472392..3475520 + 3129 WP_033071820.1 multidrug efflux RND transporter permease subunit -
C5E17_RS16435 3475753..3476001 + 249 WP_015730970.1 type B 50S ribosomal protein L31 -
C5E17_RS16440 3476019..3476162 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
C5E17_RS16445 3476921..3477289 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
C5E17_RS16450 3477345..3477548 + 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
C5E17_RS16460 3478277..3478597 + 321 WP_005976085.1 MGMT family protein -
C5E17_RS16465 3478617..3479201 - 585 WP_033071821.1 YbaY family lipoprotein -
C5E17_RS16470 3479412..3480275 + 864 WP_014700820.1 acyl-CoA thioesterase II -
C5E17_RS16475 3480393..3481679 - 1287 WP_014700821.1 ammonium transporter AmtB -
C5E17_RS16480 3481719..3482057 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T96935 WP_005976087.1 NZ_CP026977:3477345-3477548 [Pectobacterium parmentieri]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T96935 NZ_CP026977:3477345-3477548 [Pectobacterium parmentieri]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACGATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCCAATGATGAACTGGAGATGTTCTTTTCTGCAGCCGATCATCGCCTCGCAGAGTTGACGATGAACAAAC
TCTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT96935 WP_005976089.1 NZ_CP026977:3476921-3477289 [Pectobacterium parmentieri]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT96935 NZ_CP026977:3476921-3477289 [Pectobacterium parmentieri]
ATGGATGAGTACACACCAAAGCATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGATGAGAGCATAGC
AACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACTTCTGCGATCAATCTCCAATTAAATGAGCTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTCTCAGAGCAGGTTGAAAAATATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGTATTAATGACGCTGAACTACGACGCTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References